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ECOLI:CAS1

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) ygbT (synonyms: cas1)
Protein Name(s) CRISPR-associated endonuclease Cas1
External Links
UniProt Q46896
EMBL U29579
U00096
AP009048
PIR G65056
RefSeq NP_417235.1
YP_490964.1
PDB 3NKD
3NKE
4P6I
4QDL
PDBsum 3NKD
3NKE
4P6I
4QDL
ProteinModelPortal Q46896
SMR Q46896
DIP DIP-12118N
IntAct Q46896
STRING 511145.b2755
PaxDb Q46896
EnsemblBacteria AAC75797
BAE76832
GeneID 12932588
947228
KEGG ecj:Y75_p2693
eco:b2755
PATRIC 32120920
EchoBASE EB2915
EcoGene EG13114
eggNOG COG1518
HOGENOM HOG000015862
InParanoid Q46896
KO K15342
OMA FIHTGKP
OrthoDB EOG60PHDG
BioCyc EcoCyc:G7425-MONOMER
ECOL316407:JW2725-MONOMER
PRO PR:Q46896
Proteomes UP000000318
UP000000625
Genevestigator Q46896
GO GO:0005737
GO:0017108
GO:0008821
GO:0003677
GO:0046872
GO:0006974
GO:0051607
GO:0000737
GO:0006281
GO:0043571
HAMAP MF_01470
InterPro IPR002729
IPR019851
Pfam PF01867
TIGRFAMs TIGR00287
TIGR03638

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0042802

identical protein binding

PMID:24793649[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q46896

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:24561554[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q46896

F

Seeded From UniProt

complete

involved_in

GO:0043571

maintenance of CRISPR repeat elements

PMID:22402487[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017108

5'-flap endonuclease activity

PMID:21219465[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

PMID:21219465[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21219465[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002729
InterPro:IPR033641

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002729
InterPro:IPR033641

F

Seeded From UniProt

complete

enables

GO:0004520

endodeoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019851

F

Seeded From UniProt

complete

involved_in

GO:0043571

maintenance of CRISPR repeat elements

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002729
InterPro:IPR019851
InterPro:IPR033641

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002729
InterPro:IPR019851
InterPro:IPR033641

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002729
InterPro:IPR033641

P

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078402

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078402

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078402

F

Seeded From UniProt

complete

involved_in

GO:0043571

maintenance of CRISPR repeat elements

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000078402

P

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Nuñez, JK et al. (2014) Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat. Struct. Mol. Biol. 21 528-34 PubMed GONUTS page
  2. Rajagopala, SV et al. (2014) The binary protein-protein interaction landscape of Escherichia coli. Nat. Biotechnol. 32 285-90 PubMed GONUTS page
  3. Yosef, I et al. (2012) Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli. Nucleic Acids Res. 40 5569-76 PubMed GONUTS page
  4. 4.0 4.1 4.2 Babu, M et al. (2011) A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Mol. Microbiol. 79 484-502 PubMed GONUTS page