ECOLI:AQPZ

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	aqpZ (synonyms: bniP)
Protein Name(s)	Aquaporin Z Bacterial nodulin-like intrinsic protein
External Links
UniProt	P60844
EMBL	U38664 D49469 U00096 AP009048
PIR	C64826
RefSeq	NP_415396.1 YP_489148.1
PDB	1RC2 2ABM 2O9D 2O9E 2O9F 2O9G 3NK5 3NKA 3NKC
PDBsum	1RC2 2ABM 2O9D 2O9E 2O9F 2O9G 3NK5 3NKA 3NKC
ProteinModelPortal	P60844
SMR	P60844
DIP	DIP-35499N
STRING	511145.b0875
TCDB	1.A.8.3.1
EnsemblBacteria	AAC73962 BAA35589
GeneID	12931006 945497
KEGG	ecj:Y75_p0848 eco:b0875
PATRIC	32116957
EchoBASE	EB1283
EcoGene	EG13270
eggNOG	COG0580
HOGENOM	HOG000288286
InParanoid	P60844
KO	K06188
OMA	IPIDNTS
OrthoDB	EOG6GFGN7
PhylomeDB	P60844
BioCyc	EcoCyc:AQPZ-MONOMER ECOL316407:JW0859-MONOMER MetaCyc:AQPZ-MONOMER
EvolutionaryTrace	P60844
PRO	PR:P60844
Proteomes	UP000000318 UP000000625
Genevestigator	P60844
GO	GO:0016021 GO:0005886 GO:0015250 GO:0009992 GO:0006970 GO:0006833
Gene3D	1.20.1080.10
HAMAP	MF_01146
InterPro	IPR023271 IPR023743 IPR000425 IPR022357
PANTHER	PTHR19139
Pfam	PF00230
PRINTS	PR00783
SUPFAM	SSF81338
TIGRFAMs	TIGR00861
PROSITE	PS00221

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006833	water transport	PMID:16385074^[1]	ECO:0000315			P	Figure 1: The osmotic permeability is much greater in the wild-type(Fig.1A) strain compared to the (ΔaqpZ::Cam+) strain (Fig.1B).	complete CACAO 4304
involved_in	GO:0006833	water transport	PMID:16385074^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13270 FB:FBgn0000180 FB:FBgn0015872 MGI:MGI:103201 PANTHER:PTN000440616 RGD:2143 UniProtKB:P06624	C	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13270 FB:FBgn0015872 MGI:MGI:107387 MGI:MGI:1096865 MGI:MGI:96990 PANTHER:PTN000440616 RGD:2141 RGD:2143 RGD:3090 UniProtKB:P06624 UniProtKB:P29972 UniProtKB:P30301 UniProtKB:P41181 UniProtKB:P55064 UniProtKB:P55087 UniProtKB:Q5A1Z4 ZFIN:ZDB-GENE-030131-7764 ZFIN:ZDB-GENE-040801-41	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13270 FB:FBgn0000180 MGI:MGI:103201 MGI:MGI:106215 MGI:MGI:107387 MGI:MGI:1096865 MGI:MGI:96990 PANTHER:PTN000440616 RGD:2141 RGD:2142 RGD:2143 RGD:2144 RGD:3090 UniProtKB:K7N7A8 UniProtKB:P06624 UniProtKB:P29972 UniProtKB:P30301 UniProtKB:P41181 UniProtKB:P55064 UniProtKB:P55087 UniProtKB:Q5A1Z4	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24899312^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60844	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20855585^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60844	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16239219^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60844	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:14691544^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60844	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:20008071^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16239219^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10518952^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:10400575^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:14691544^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:10518952^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009992	cellular water homeostasis	PMID:9520416^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009992	cellular water homeostasis	PMID:10400575^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	PMID:10400575^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	PMID:9520416^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006833	water transport	PMID:10400575^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006833	water transport	PMID:14691544^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006833	water transport	PMID:10518952^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10518952^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10518952^[8]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
part_of	GO:0005886	plasma membrane	PMID:15919996^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006833	water transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023743	P	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023743	F	Seeded From UniProt	complete
enables	GO:0015267	channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023743	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425 InterPro:IPR023743	P	Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100767	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100767	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-KW:KW-0997 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Mallo, RC & Ashby, MT (2006) AqpZ-mediated water permeability in Escherichia coli measured by stopped-flow spectroscopy. J. Bacteriol. 188 820-2 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Laganowsky, A et al. (2014) Membrane proteins bind lipids selectively to modulate their structure and function. Nature 510 172-175 PubMed GONUTS page
↑ Savage, DF et al. (2010) Structural context shapes the aquaporin selectivity filter. Proc. Natl. Acad. Sci. U.S.A. 107 17164-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Jiang, J et al. (2006) Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel. J. Biol. Chem. 281 454-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Savage, DF et al. (2003) Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol. 1 E72 PubMed GONUTS page
↑ Romantsov, T et al. (2010) Protein localization in Escherichia coli cells: comparison of the cytoplasmic membrane proteins ProP, LacY, ProW, AqpZ, MscS, and MscL. J. Bacteriol. 192 912-24 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Borgnia, MJ et al. (1999) Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J. Mol. Biol. 291 1169-79 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Delamarche, C et al. (1999) Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J. Bacteriol. 181 4193-7 PubMed GONUTS page
↑ ^10.0 ^10.1 Calamita, G et al. (1998) Regulation of the Escherichia coli water channel gene aqpZ. Proc. Natl. Acad. Sci. U.S.A. 95 3627-31 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:16385074-1] 1.0 ^1.1 Mallo, RC & Ashby, MT (2006) AqpZ-mediated water permeability in Escherichia coli measured by stopped-flow spectroscopy. J. Bacteriol. 188 820-2 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24899312-3] Laganowsky, A et al. (2014) Membrane proteins bind lipids selectively to modulate their structure and function. Nature 510 172-175 PubMed GONUTS page

[PMID:20855585-4] Savage, DF et al. (2010) Structural context shapes the aquaporin selectivity filter. Proc. Natl. Acad. Sci. U.S.A. 107 17164-9 PubMed GONUTS page

[PMID:16239219-5] 5.0 ^5.1 Jiang, J et al. (2006) Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel. J. Biol. Chem. 281 454-60 PubMed GONUTS page

[PMID:14691544-6] 6.0 ^6.1 ^6.2 Savage, DF et al. (2003) Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z. PLoS Biol. 1 E72 PubMed GONUTS page

[PMID:20008071-7] Romantsov, T et al. (2010) Protein localization in Escherichia coli cells: comparison of the cytoplasmic membrane proteins ProP, LacY, ProW, AqpZ, MscS, and MscL. J. Bacteriol. 192 912-24 PubMed GONUTS page

[PMID:10518952-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Borgnia, MJ et al. (1999) Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J. Mol. Biol. 291 1169-79 PubMed GONUTS page

[PMID:10400575-9] 9.0 ^9.1 ^9.2 ^9.3 Delamarche, C et al. (1999) Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J. Bacteriol. 181 4193-7 PubMed GONUTS page

[PMID:9520416-10] 10.0 ^10.1 Calamita, G et al. (1998) Regulation of the Escherichia coli water channel gene aqpZ. Proc. Natl. Acad. Sci. U.S.A. 95 3627-31 PubMed GONUTS page

[PMID:15919996-11] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:AQPZ

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