ECOLI:AK3

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	lysC (synonyms: apk)
Protein Name(s)	Lysine-sensitive aspartokinase 3 Aspartate kinase III AKIII Lysine-sensitive aspartokinase III
External Links
UniProt	P08660
EMBL	M11812 U00006 U00096 AP009048 X00008
PIR	G65209
RefSeq	NP_418448.1 YP_492167.1
PDB	2J0W 2J0X
PDBsum	2J0W 2J0X
ProteinModelPortal	P08660
SMR	P08660
STRING	511145.b4024
PaxDb	P08660
PRIDE	P08660
EnsemblBacteria	AAC76994 BAE78026
GeneID	12932961 948531
KEGG	ecj:Y75_p3911 eco:b4024
PATRIC	32123577
EchoBASE	EB0545
EcoGene	EG10550
eggNOG	COG0527
HOGENOM	HOG000293094
InParanoid	P08660
KO	K00928
OMA	PFNLRMI
OrthoDB	EOG6M0T34
PhylomeDB	P08660
BioCyc	EcoCyc:ASPKINIII-MONOMER ECOL316407:JW3984-MONOMER MetaCyc:ASPKINIII-MONOMER
SABIO-RK	P08660
UniPathway	UPA00034
EvolutionaryTrace	P08660
PRO	PR:P08660
Proteomes	UP000000318 UP000000625
Genevestigator	P08660
GO	GO:0016597 GO:0004072 GO:0005524 GO:0009090 GO:0009089
Gene3D	3.40.1160.10
InterPro	IPR002912 IPR001048 IPR005260 IPR001341 IPR018042
Pfam	PF00696 PF01842
PIRSF	PIRSF000726
SUPFAM	SSF53633
TIGRFAMs	TIGR00656 TIGR00657
PROSITE	PS51671 PS00324

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0009090	homoserine biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 SGD:S000000854	P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 UniProtKB:P9WPX3	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076	C	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 SGD:S000000854 TAIR:locus:2078638 TAIR:locus:2174708 UniProtKB:P94417 UniProtKB:P9WPX3	F	Seeded From UniProt	complete
involved_in	GO:0009090	homoserine biosynthetic process	PMID:6249791^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	PMID:6249791^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	PMID:6249791^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	PMID:14623187^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001341 InterPro:IPR005260 InterPro:IPR018042	F	Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001341 InterPro:IPR018042	P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005260	P	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.2.4	F	Seeded From UniProt	complete
involved_in	GO:0009085	lysine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0457	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0028	P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00034	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Richaud, F et al. (1980) Regulation of aspartokinase III synthesis in Escherichia coli: isolation of mutants containing lysC-lac fusions. J. Bacteriol. 143 513-5 PubMed GONUTS page
↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
↑ Marco-Marín, C et al. (2003) Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase. J. Mol. Biol. 334 459-76 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:6249791-2] 2.0 ^2.1 ^2.2 Richaud, F et al. (1980) Regulation of aspartokinase III synthesis in Escherichia coli: isolation of mutants containing lysC-lac fusions. J. Bacteriol. 143 513-5 PubMed GONUTS page

[PMID:18304323-3] Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[PMID:14623187-4] Marco-Marín, C et al. (2003) Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase. J. Mol. Biol. 334 459-76 PubMed GONUTS page

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ECOLI:AK3

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