ECOLI:AK2H

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	metL (synonyms: metM)
Protein Name(s)	Bifunctional aspartokinase/homoserine dehydrogenase 2 Aspartokinase II/homoserine dehydrogenase II AKII-HDII Aspartokinase Homoserine dehydrogenase
External Links
UniProt	P00562
EMBL	V00305 L19201 U00096 AP009048
PIR	S40883
RefSeq	NP_418375.1 YP_491511.1
ProteinModelPortal	P00562
SMR	P00562
DIP	DIP-10197N
IntAct	P00562
STRING	511145.b3940
PaxDb	P00562
PRIDE	P00562
EnsemblBacteria	AAC76922 BAE77370
GeneID	12932107 948433
KEGG	ecj:Y75_p3247 eco:b3940
PATRIC	32123399
EchoBASE	EB0585
EcoGene	EG10590
eggNOG	COG0527
HOGENOM	HOG000271594
InParanoid	P00562
KO	K12525
OMA	TLQYPEF
OrthoDB	EOG6M0T34
PhylomeDB	P00562
BioCyc	EcoCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER ECOL316407:JW3911-MONOMER MetaCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER
UniPathway	UPA00034 UPA00050 UPA00050 UPA00051 UPA00051
PRO	PR:P00562
Proteomes	UP000000318 UP000000625
Genevestigator	P00562
GO	GO:0004072 GO:0005524 GO:0004412 GO:0050661 GO:0009090 GO:0009089 GO:0009086 GO:0009088
Gene3D	3.40.1160.10 3.40.50.720
InterPro	IPR001048 IPR005106 IPR001341 IPR018042 IPR011147 IPR001342 IPR019811 IPR016040
Pfam	PF00696 PF00742 PF03447
PIRSF	PIRSF000727
SUPFAM	SSF53633
TIGRFAMs	TIGR00657
PROSITE	PS00324 PS01042

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0009090	homoserine biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 SGD:S000000854	P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 UniProtKB:P9WPX3	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076	C	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10550 EcoGene:EG10590 PANTHER:PTN000487076 SGD:S000000854 TAIR:locus:2078638 TAIR:locus:2174708 UniProtKB:P94417 UniProtKB:P9WPX3	F	Seeded From UniProt	complete
involved_in	GO:0009090	homoserine biosynthetic process	PMID:4889171^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	PMID:4889171^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004412	homoserine dehydrogenase activity	PMID:4889171^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	PMID:4889171^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001341 InterPro:IPR011147 InterPro:IPR018042	F	Seeded From UniProt	complete
enables	GO:0004412	homoserine dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011147	F	Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001342 InterPro:IPR019811	P	Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001341 InterPro:IPR018042	P	Seeded From UniProt	complete
involved_in	GO:0009067	aspartate family amino acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011147	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005106	F	Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005106	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001342 InterPro:IPR005106 InterPro:IPR011147 InterPro:IPR019811	P	Seeded From UniProt	complete
enables	GO:0004412	homoserine dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.3	F	Seeded From UniProt	complete
enables	GO:0004072	aspartate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.2.4	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0009086	methionine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0486	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0028	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0009088	threonine biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00050	P	Seeded From UniProt	complete
involved_in	GO:0009089	lysine biosynthetic process via diaminopimelate	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00034	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Falcoz-Kelly, F et al. (1969) The methionine-repressible homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Preparation of the homogeneous protein catalyzing the two activities. Molecular weight of the native enzyme and of its subunits. Eur. J. Biochem. 8 146-52 PubMed GONUTS page
↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:4889171-2] 2.0 ^2.1 ^2.2 ^2.3 Falcoz-Kelly, F et al. (1969) The methionine-repressible homoserine dehydrogenase and aspartokinase activities of Escherichia coli K 12. Preparation of the homogeneous protein catalyzing the two activities. Molecular weight of the native enzyme and of its subunits. Eur. J. Biochem. 8 146-52 PubMed GONUTS page

[PMID:18304323-3] Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page

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ECOLI:AK2H

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