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ECOLI:ADA
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | ada | |
| Protein Name(s) | Bifunctional transcriptional activator/DNA repair enzyme Ada
Regulatory protein of adaptive response Methylphosphotriester-DNA--protein-cysteine S-methyltransferase Methylphosphotriester-DNA methyltransferase Methylated-DNA--protein-cysteine methyltransferase O6-methylguanine-DNA alkyltransferase | |
| External Links | ||
| UniProt | P06134 | |
| EMBL | M10211 M10315 U00008 U00096 AP009048 J02607 M13155 M13828 | |
| PIR | C64991 | |
| RefSeq | NP_416717.1 YP_490451.1 | |
| PDB | 1ADN 1EYF 1SFE 1U8B 1WPK 1ZGW | |
| PDBsum | 1ADN 1EYF 1SFE 1U8B 1WPK 1ZGW | |
| ProteinModelPortal | P06134 | |
| SMR | P06134 | |
| DIP | DIP-9055N | |
| IntAct | P06134 | |
| MINT | MINT-1310041 | |
| STRING | 511145.b2213 | |
| PRIDE | P06134 | |
| EnsemblBacteria | AAC75273 BAA15996 | |
| GeneID | 12932929 946710 | |
| KEGG | ecj:Y75_p2174 eco:b2213 | |
| PATRIC | 32119785 | |
| EchoBASE | EB0028 | |
| EcoGene | EG10029 | |
| eggNOG | COG2169 | |
| HOGENOM | HOG000244139 | |
| InParanoid | P06134 | |
| KO | K10778 | |
| OMA | RFAIGQC | |
| OrthoDB | EOG6WMJ4F | |
| PhylomeDB | P06134 | |
| BioCyc | EcoCyc:PD00230 ECOL316407:JW2201-MONOMER MetaCyc:PD00230 | |
| EvolutionaryTrace | P06134 | |
| PRO | PR:P06134 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P06134 | |
| GO | GO:0003908 GO:0043565 GO:0003700 GO:0008270 GO:0006307 GO:0080111 GO:0006351 | |
| Gene3D | 1.10.10.10 1.10.10.60 3.40.10.10 | |
| InterPro | IPR004026 IPR016221 IPR009057 IPR018060 IPR018062 IPR001497 IPR014048 IPR008332 IPR011991 | |
| Pfam | PF02805 PF01035 PF00165 PF02870 | |
| PIRSF | PIRSF000409 | |
| SMART | SM00342 | |
| SUPFAM | SSF46689 SSF46767 SSF53155 SSF57884 | |
| TIGRFAMs | TIGR00589 | |
| PROSITE | PS00041 PS01124 PS00374 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0003908 |
methylated-DNA-(protein)-cysteine S-methyltransferase activity |
ECO:0000315 |
F |
The number of spontaneous mutations from G:C to A:T and G:C to C:G increases 4 fold in ada ogt double mutants (Table 2). |
complete | |||||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006307 |
DNA dealkylation involved in DNA repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003908 |
methylated-DNA-[protein]-cysteine S-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0080111 |
DNA demethylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018125 |
peptidyl-cysteine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018125 |
peptidyl-cysteine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003908 |
methylated-DNA-[protein]-cysteine S-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003908 |
methylated-DNA-[protein]-cysteine S-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003908 |
methylated-DNA-[protein]-cysteine S-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001497 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003908 |
methylated-DNA-[protein]-cysteine S-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Demple, B et al. (1982) Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase. J. Biol. Chem. 257 13776-80 PubMed GONUTS page
- ↑ Mackay, WJ et al. (1994) DNA alkylation repair limits spontaneous base substitution mutations in Escherichia coli. J. Bacteriol. 176 3224-30 PubMed GONUTS page
- ↑ Myers, LC et al. (1992) Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein. Biochemistry 31 4541-7 PubMed GONUTS page
- ↑ Schendel, PF & Robins, PE (1978) Repair of O6-methylguanine in adapted Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 75 6017-20 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lindahl, T et al. (1982) Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. EMBO J. 1 1359-63 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Nakabeppu, Y et al. (1985) Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase. J. Biol. Chem. 260 7281-8 PubMed GONUTS page
- ↑ 7.0 7.1 Saget, BM & Walker, GC (1994) The Ada protein acts as both a positive and a negative modulator of Escherichia coli's response to methylating agents. Proc. Natl. Acad. Sci. U.S.A. 91 9730-4 PubMed GONUTS page
- ↑ Lemotte, PK & Walker, GC (1985) Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents. J. Bacteriol. 161 888-95 PubMed GONUTS page
- ↑ Sedgwick, B & Lindahl, T (2002) Recent progress on the Ada response for inducible repair of DNA alkylation damage. Oncogene 21 8886-94 PubMed GONUTS page
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