ECOLI:ACSA

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	acs (ECO:0000255 with HAMAP-Rule:MF_01123) (synonyms: yfaC)
Protein Name(s)	Acetyl-coenzyme A synthetase (ECO:0000255 with HAMAP-Rule:MF_01123) AcCoA synthetase (ECO:0000255 with HAMAP-Rule:MF_01123) Acs (ECO:0000255 with HAMAP-Rule:MF_01123) Acetate--CoA ligase (ECO:0000255 with HAMAP-Rule:MF_01123) Acyl-activating enzyme (ECO:0000255 with HAMAP-Rule:MF_01123)
External Links
UniProt	P27550
EMBL	U00006 U00096 AP009048 M87509
PIR	D65215
RefSeq	NP_418493.1 YP_492212.1
ProteinModelPortal	P27550
SMR	P27550
IntAct	P27550
STRING	511145.b4069
PaxDb	P27550
PRIDE	P27550
EnsemblBacteria	AAC77039 BAE78071
GeneID	12933681 948572
KEGG	ecj:Y75_p3956 eco:b4069
PATRIC	32123687
EchoBASE	EB1417
EcoGene	EG11448
eggNOG	COG0365
HOGENOM	HOG000229981
InParanoid	P27550
KO	K01895
OMA	SHRCLTI
OrthoDB	EOG68WR2H
PhylomeDB	P27550
BioCyc	EcoCyc:ACS-MONOMER ECOL316407:JW4030-MONOMER MetaCyc:ACS-MONOMER
PRO	PR:P27550
Proteomes	UP000000318 UP000000625
Genevestigator	P27550
GO	GO:0003987 GO:0016208 GO:0005524 GO:0046872 GO:0050218 GO:0033558 GO:0045733 GO:0019427 GO:0006935 GO:0018394 GO:0034421 GO:0006476
HAMAP	MF_01123
InterPro	IPR011904 IPR025110 IPR020845 IPR000873
Pfam	PF00501 PF13193
TIGRFAMs	TIGR02188
PROSITE	PS00455

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003987	acetate-CoA ligase activity	PMID:7751300	ECO:0000314			F		Figure 9. Also, Table 3 shows that Acs deficient strains were not able to activate acetate as well as the wild-type strain.	complete CACAO 4886
	GO:0018394	peptidyl-lysine acetylation	PMID:15327942	ECO:0000314			P		Figure 3. Purified Acs was incubated with ATP, Mg2+, and acetate. Western blotting with anti-acetyl-lysine antibody showed lysine acetylation of Acs.	complete CACAO 5127
	GO:0034421	post-translational protein acetylation	PMID:15327942	ECO:0000314			P		Figure 3. Purified Acs was incubated with Mg2+, ATP, and acetate. Acs showed acetylation.	complete CACAO 5128
	GO:0033558	protein deacetylase activity	PMID:16630631	ECO:0000314			F		Figure 5b. Acs can catalyze deacetylation of CheY.	complete CACAO 5138
involved_in	GO:0034421	post-translational protein acetylation	PMID:15327942	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:16630631	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018394	peptidyl-lysine acetylation	PMID:15327942	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003987	acetate-CoA ligase activity	PMID:7751300	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045733	acetate catabolic process	PMID:7751300	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050218	propionate-CoA ligase activity	PMID:15327942	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045733	acetate catabolic process	PMID:7751300	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003987	acetate-CoA ligase activity	PMID:7751300	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0033558	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000873	F		Seeded From UniProt	complete
enables	GO:0003987	acetate-CoA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011904	F		Seeded From UniProt	complete
enables	GO:0016208	AMP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011904	F		Seeded From UniProt	complete
involved_in	GO:0019427	acetyl-CoA biosynthetic process from acetate	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011904	P		Seeded From UniProt	complete
enables	GO:0003987	acetate-CoA ligase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:6.2.1.1	F		Seeded From UniProt	complete
involved_in	GO:0019427	acetyl-CoA biosynthetic process from acetate	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100676	P		Seeded From UniProt	complete
enables	GO:0003987	acetate-CoA ligase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100676	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100676	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
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References

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