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ECOHS:NSRR

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Species (Taxon ID) Escherichia coli O9:H4 (strain HS). (331112)
Gene Name(s) nsrR (ECO:0000255 with HAMAP-Rule:MF_01177)
Protein Name(s) HTH-type transcriptional repressor NsrR (ECO:0000255 with HAMAP-Rule:MF_01177)
External Links
UniProt A8A7S3
EMBL CP000802
RefSeq YP_001460960.1
ProteinModelPortal A8A7S3
STRING 331112.EcHS_A4421
EnsemblBacteria ABV08577
GeneID 5592711
KEGG ecx:EcHS_A4421
PATRIC 18318822
eggNOG COG1959
HOGENOM HOG000249814
KO K13771
OMA QQAVQNF
OrthoDB EOG6BGP3D
BioCyc ECOL331112:GHHI-4413-MONOMER
Proteomes UP000001123
GO GO:0051537
GO:0003690
GO:0005506
GO:0003700
GO:0045892
GO:0006351
Gene3D 1.10.10.10
HAMAP MF_01177
InterPro IPR000944
IPR023761
IPR011991
Pfam PF02082
TIGRFAMs TIGR00738
PROSITE PS01332
PS51197

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR023761

P

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100856

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100856

P

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100856

F

Seeded From UniProt

complete

GO:1900488

negative regulation of [2Fe-2S] cluster assembly

PMID:8989365[1]

ECO:0000314

P

Figure 3 : DNA binding assays with the hmpA1 and hmpA2 promoters and purified NsrR protein.shows the loss of DNA binding activity. This is the first demonstration that NsrR contains an NO-sensitive [2Fe-2S] cluster that is required for DNA binding activity.

complete
CACAO 10729

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000100856

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0051537

2 iron, 2 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0001

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Manti, L et al. (1997) Genomic instability in Chinese hamster cells after exposure to X rays or alpha particles of different mean linear energy transfer. Radiat. Res. 147 22-8 PubMed GONUTS page