GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

ECO27:CLPX

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Escherichia coli O127:H6 (strain E2348/69 / EPEC). (574521)
Gene Name(s) clpX (ECO:0000255 with HAMAP-Rule:MF_00175)
Protein Name(s) ATP-dependent Clp protease ATP-binding subunit ClpX (ECO:0000255 with HAMAP-Rule:MF_00175)
External Links
UniProt B7UJR1
EMBL FM180568
RefSeq YP_002327950.1
ProteinModelPortal B7UJR1
SMR B7UJR1
STRING 574521.E2348C_0373
PRIDE B7UJR1
EnsemblBacteria CAS07921
GeneID 7062810
KEGG ecg:E2348C_0373
PATRIC 18339712
eggNOG COG1219
KO K03544
OMA ILLDIMY
OrthoDB EOG625JZK
BioCyc ECOL574521:GJAO-385-MONOMER
Proteomes UP000008205
GO GO:0005524
GO:0008270
GO:0006457
Gene3D 3.40.50.300
HAMAP MF_00175
InterPro IPR003593
IPR003959
IPR019489
IPR004487
IPR027417
IPR010603
Pfam PF07724
PF10431
PF06689
SMART SM00382
SM01086
SM00994
SUPFAM SSF52540
TIGRFAMs TIGR00382

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043335

protein unfolding

PMID:21529717[1]

ECO:0000314

P

Figure 4 - ClpX unfolds GFP.

complete
CACAO 9058

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003959
InterPro:IPR004487

F

Seeded From UniProt

complete

GO:0010498

proteasomal protein catabolic process

PMID:9573050[2]

ECO:0000314

P

Figure 4 - ClpX works with ClpP in vitro to degrade tagged protein.

complete
CACAO 9059

involved_in

GO:0006457

protein folding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004487

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010603

F

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010603

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004487

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001454

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001454

F

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000001454

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Maillard, RA et al. (2011) ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell 145 459-69 PubMed GONUTS page
  2. Gottesman, S et al. (1998) The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. Genes Dev. 12 1338-47 PubMed GONUTS page