EBOZM:VP24

Species (Taxon ID)	Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus). (128952)
Gene Name(s)	VP24
Protein Name(s)	Membrane-associated protein VP24
External Links
UniProt	Q05322
EMBL	L11365 AF086833 AF272001 AY142960 AF499101
RefSeq	NP_066250.1
PDB	4M0Q 4U2X
PDBsum	4M0Q 4U2X
IntAct	Q05322
GeneID	911828
Proteomes	UP000007209
GO	GO:0033645 GO:0020002 GO:0055036 GO:0005198 GO:0046774 GO:0046761
InterPro	IPR009433
Pfam	PF06389
PIRSF	PIRSF011355

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046774	suppression by virus of host intracellular interferon activity	PMID:16698996	ECO:0000314			P		Figure 1: ISG54- CAT is a reporter gene that is induced by IFN-β. 1A shows that the expression is inhibited significantly when both VP24 and flagged VP24 are present. STAT1 expression is also induced by IFN-β and is key in the antiviral response. 1B shows a Western blot of STAT1 expression, which is also inhibited by VP24. A Lucerifase reporter was placed under control of a promoter that responds to INF-γ induction and the activity reported in 1C. INF-γ is also inhibited by VP24.	complete CACAO 6388
	GO:0020002	host cell plasma membrane	PMID:12525613	ECO:0000314			C		Figure 2: This indirect immunofluorescence analysis demonstrates the localization of VP24 into the plasma membrane.	complete CACAO 6402
	GO:0046761	viral budding from plasma membrane	PMID:12525613	ECO:0000314			P		Figure 7: This figure shows the results of SDS-PAGE that detected VP24 in the budding virus like particles.	complete CACAO 6403
involved_in	GO:0046774	suppression by virus of host intracellular interferon activity	PMID:16698996	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046761	viral budding from plasma membrane	PMID:12525613	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	PMID:12525613	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009433	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009433	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009433	P		Seeded From UniProt	complete
involved_in	GO:0039502	suppression by virus of host type I interferon-mediated signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1114	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946	C		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899 UniProtKB-KW:KW-0922	P		Seeded From UniProt	complete
involved_in	GO:0039563	suppression by virus of host STAT1 activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1105	P		Seeded From UniProt	complete
part_of	GO:0020002	host cell plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1032 UniProtKB-SubCell:SL-0375	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0033645	host cell endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0398	C		Seeded From UniProt	complete
part_of	GO:0055036	virion membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0275	C		Seeded From UniProt	complete
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