DROME:TBH1

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Tbh
Protein Name(s)	Tyramine beta-hydroxylase
External Links
UniProt	Q86B61
EMBL	Z70316 AE014298 BT025901
RefSeq	NP_001284996.1 NP_788884.1
ProteinModelPortal	Q86B61
SMR	Q86B61
PaxDb	Q86B61
PRIDE	Q86B61
EnsemblMetazoa	FBtr0089999
GeneID	31718
KEGG	dme:Dmel_CG1543
CTD	31718
FlyBase	FBgn0010329
eggNOG	NOG286384
GeneTree	ENSGT00530000063085
InParanoid	Q86B61
KO	K00503
OMA	SYFGDAW
OrthoDB	EOG78WKR4
PhylomeDB	Q86B61
BioCyc	MetaCyc:MONOMER-18080
Reactome	REACT_258043
SignaLink	Q86B61
GenomeRNAi	31718
NextBio	774994
PRO	PR:Q86B61
Proteomes	UP000000803
Bgee	Q86B61
GO	GO:0016021 GO:0005507 GO:0016715 GO:0002118 GO:0048149 GO:0007629 GO:0002121 GO:0008345 GO:0007612 GO:0040011 GO:0008049 GO:0048047 GO:0007613 GO:0006589 GO:0071927 GO:0030728 GO:0050795 GO:0043059
Gene3D	2.60.120.230 2.60.120.310
InterPro	IPR014784 IPR020611 IPR000323 IPR000945 IPR005018 IPR008977 IPR028460
PANTHER	PTHR10157 PTHR10157:SF4
Pfam	PF01082 PF03351
PRINTS	PR00767
SMART	SM00664
SUPFAM	SSF49742
PROSITE	PS00084 PS50836

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009007	site-specific DNA-methyltransferase (adenine-specific) activity	PMID:8656284^[1]	ECO:0000314			F	Figure 2	complete CACAO 6063
	GO:0021858	GABAergic neuron differentiation in basal ganglia	PMID:8656284^[1]	ECO:0000314			P	Figure 6	complete CACAO 6065
involved_in	GO:0040011	locomotion	PMID:14978721^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	PMID:8656284^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042421	norepinephrine biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 RGD:2489 UniProtKB:P09172	P	Seeded From UniProt	complete
involved_in	GO:0042420	dopamine catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 UniProtKB:P09172 UniProtKB:P15101	P	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:94864 PANTHER:PTN000806665 UniProtKB:P09172	C	Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010329 PANTHER:PTN001605435	F	Seeded From UniProt	complete
involved_in	GO:0006589	octopamine biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 WB:WBGene00006541	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001605435 RGD:2489	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 UniProtKB:P09172 UniProtKB:P15101	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001605435 RGD:2489 UniProtKB:P09172 UniProtKB:P15101	F	Seeded From UniProt	complete
enables	GO:0004500	dopamine beta-monooxygenase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000806665 RGD:2489 UniProtKB:P09172 UniProtKB:P15101	F	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:23055498^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:23055498^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:21206762^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048047	mating behavior, sex discrimination	PMID:20967276^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0004652	P	Seeded From UniProt	complete
involved_in	GO:0002118	aggressive behavior	PMID:19160504^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002121	inter-male aggressive behavior	PMID:19160504^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071927	octopamine signaling pathway	PMID:17928454^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007629	flight behavior	PMID:17928454^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008345	larval locomotory behavior	PMID:17638385^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:17360588^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	PMID:17360588^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043059	regulation of forward locomotion	PMID:16452672^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	PMID:14623230^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:14627633^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:11086999^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008977	F	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR036939	F	Seeded From UniProt	complete
enables	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR036939	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000323 InterPro:IPR014784 InterPro:IPR020611 InterPro:IPR028460 InterPro:IPR036939	P	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:12490253^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006589	octopamine biosynthetic process	PMID:12490253^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0042136	neurotransmitter biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0530	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Monastirioti, M et al. (1996) Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine. J. Neurosci. 16 3900-11 PubMed GONUTS page
↑ Saraswati, S et al. (2004) Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae. J. Neurobiol. 58 425-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhou, C et al. (2012) Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J. Neurosci. 32 14281-7 PubMed GONUTS page
↑ Yarali, A & Gerber, B (2010) A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila. Front Behav Neurosci 4 189 PubMed GONUTS page
↑ Certel, SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS ONE 5 e13248 PubMed GONUTS page
↑ ^7.0 ^7.1 Zhou, C et al. (2008) A subset of octopaminergic neurons are important for Drosophila aggression. Nat. Neurosci. 11 1059-67 PubMed GONUTS page
↑ ^8.0 ^8.1 Brembs, B et al. (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. J. Neurosci. 27 11122-31 PubMed GONUTS page
↑ Hardie, SL et al. (2007) Trace amines differentially regulate adult locomotor activity, cocaine sensitivity, and female fertility in Drosophila melanogaster. Dev Neurobiol 67 1396-405 PubMed GONUTS page
↑ ^10.0 ^10.1 Certel, SJ et al. (2007) Modulation of Drosophila male behavioral choice. Proc. Natl. Acad. Sci. U.S.A. 104 4706-11 PubMed GONUTS page
↑ Fox, LE et al. (2006) Coordination and modulation of locomotion pattern generators in Drosophila larvae: effects of altered biogenic amine levels by the tyramine beta hydroxlyase mutation. J. Neurosci. 26 1486-98 PubMed GONUTS page
↑ Monastirioti, M (2003) Distinct octopamine cell population residing in the CNS abdominal ganglion controls ovulation in Drosophila melanogaster. Dev. Biol. 264 38-49 PubMed GONUTS page
↑ Schwaerzel, M et al. (2003) Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila. J. Neurosci. 23 10495-502 PubMed GONUTS page
↑ Scholz, H et al. (2000) Functional ethanol tolerance in Drosophila. Neuron 28 261-71 PubMed GONUTS page
↑ ^15.0 ^15.1 Rothenfluh, A & Heberlein, U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr. Opin. Neurobiol. 12 639-45 PubMed GONUTS page

[PMID:8656284-1] 1.0 ^1.1 ^1.2 Monastirioti, M et al. (1996) Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine. J. Neurosci. 16 3900-11 PubMed GONUTS page

[PMID:14978721-2] Saraswati, S et al. (2004) Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae. J. Neurobiol. 58 425-41 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23055498-4] 4.0 ^4.1 Zhou, C et al. (2012) Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J. Neurosci. 32 14281-7 PubMed GONUTS page

[PMID:21206762-5] Yarali, A & Gerber, B (2010) A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila. Front Behav Neurosci 4 189 PubMed GONUTS page

[PMID:20967276-6] Certel, SJ et al. (2010) Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS ONE 5 e13248 PubMed GONUTS page

[PMID:19160504-7] 7.0 ^7.1 Zhou, C et al. (2008) A subset of octopaminergic neurons are important for Drosophila aggression. Nat. Neurosci. 11 1059-67 PubMed GONUTS page

[PMID:17928454-8] 8.0 ^8.1 Brembs, B et al. (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. J. Neurosci. 27 11122-31 PubMed GONUTS page

[PMID:17638385-9] Hardie, SL et al. (2007) Trace amines differentially regulate adult locomotor activity, cocaine sensitivity, and female fertility in Drosophila melanogaster. Dev Neurobiol 67 1396-405 PubMed GONUTS page

[PMID:17360588-10] 10.0 ^10.1 Certel, SJ et al. (2007) Modulation of Drosophila male behavioral choice. Proc. Natl. Acad. Sci. U.S.A. 104 4706-11 PubMed GONUTS page

[PMID:16452672-11] Fox, LE et al. (2006) Coordination and modulation of locomotion pattern generators in Drosophila larvae: effects of altered biogenic amine levels by the tyramine beta hydroxlyase mutation. J. Neurosci. 26 1486-98 PubMed GONUTS page

[PMID:14623230-12] Monastirioti, M (2003) Distinct octopamine cell population residing in the CNS abdominal ganglion controls ovulation in Drosophila melanogaster. Dev. Biol. 264 38-49 PubMed GONUTS page

[PMID:14627633-13] Schwaerzel, M et al. (2003) Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila. J. Neurosci. 23 10495-502 PubMed GONUTS page

[PMID:11086999-14] Scholz, H et al. (2000) Functional ethanol tolerance in Drosophila. Neuron 28 261-71 PubMed GONUTS page

[PMID:12490253-15] 15.0 ^15.1 Rothenfluh, A & Heberlein, U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr. Opin. Neurobiol. 12 639-45 PubMed GONUTS page

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DROME:TBH1

Contents

Annotations

Notes

References

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