It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Tuesday November 21, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:TBB1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) betaTub56D
Protein Name(s) Tubulin beta-1 chain

Beta-1-tubulin

External Links
UniProt Q24560
EMBL M20419
AE013599
BT003242
RefSeq NP_523795.2
UniGene Dm.7174
ProteinModelPortal Q24560
SMR Q24560
BioGrid 62900
DIP DIP-43956N
IntAct Q24560
MINT MINT-786821
STRING 7227.FBpp0085721
PaxDb Q24560
PRIDE Q24560
EnsemblMetazoa FBtr0086536
GeneID 37238
KEGG dme:Dmel_CG9277
CTD 37238
FlyBase FBgn0003887
eggNOG COG5023
GeneTree ENSGT00760000119061
InParanoid Q24560
KO K07375
OrthoDB EOG71ZP1H
PhylomeDB Q24560
Reactome REACT_238475
REACT_239431
REACT_248438
REACT_269710
ChiTaRS betaTub56D
GenomeRNAi 37238
NextBio 802687
Proteomes UP000000803
Bgee Q24560
ExpressionAtlas Q24560
GO GO:0005737
GO:0005874
GO:0005525
GO:0003924
GO:0005200
GO:0051298
GO:0016203
GO:0051258
Gene3D 1.10.287.600
3.30.1330.20
3.40.50.1440
InterPro IPR013838
IPR002453
IPR008280
IPR000217
IPR018316
IPR023123
IPR017975
IPR003008
PANTHER PTHR11588
Pfam PF00091
PF03953
PRINTS PR01163
PR01161
SMART SM00864
SM00865
SUPFAM SSF52490
SSF55307
PROSITE PS00227
PS00228

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009790

embryo development

PMID:8692694[1]

IDA: Inferred from Direct Assay

P

Figure 1-1 Tubulin mRNA distribution during embryogenesis.

complete
CACAO 6073

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0003924

GTPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003008
InterPro:IPR008280

F

Seeded From UniProt

complete

GO:0005200

structural constituent of cytoskeleton

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002453

F

Seeded From UniProt

complete

GO:0005200

structural constituent of cytoskeleton

PMID:10790333[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005200

structural constituent of cytoskeleton

PMID:10908588[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002453
InterPro:IPR008280
InterPro:IPR017975

F

Seeded From UniProt

complete

GO:0005525

GTP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:24292889[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000217
InterPro:IPR002453
InterPro:IPR017975

C

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

GO:0005874

microtubule

PMID:10790333[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005874

microtubule

PMID:10908588[3]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005874

microtubule

PMID:11514618[5]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0007017

microtubule-based process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000217
InterPro:IPR002453
InterPro:IPR017975

P

Seeded From UniProt

complete

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003008
InterPro:IPR008280

P

Seeded From UniProt

complete

GO:0016203

muscle attachment

PMID:10218153[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043234

protein complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

C

Seeded From UniProt

complete

GO:0051258

protein polymerization

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008280

P

Seeded From UniProt

complete

GO:0051298

centrosome duplication

PMID:20818332[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Köhler, J et al. (1996) Related enhancers in the intron of the beta1 tubulin gene of Drosophila melanogaster are essential for maternal and CNS-specific expression during embryogenesis. Nucleic Acids Res. 24 2543-50 PubMed GONUTS page
  2. 2.0 2.1 Hoyle, HD et al. (2000) A transient specialization of the microtubule cytoskeleton is required for differentiation of the Drosophila visual system. Dev. Biol. 221 375-89 PubMed GONUTS page
  3. 3.0 3.1 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  4. Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page
  5. Kondylis, V et al. (2001) Biogenesis of Golgi stacks in imaginal discs of Drosophila melanogaster. Mol. Biol. Cell 12 2308-27 PubMed GONUTS page
  6. Bate, M et al. (1999) Development of larval body wall muscles. Int. Rev. Neurobiol. 43 25-44 PubMed GONUTS page
  7. Müller, H et al. (2010) Proteomic and functional analysis of the mitotic Drosophila centrosome. EMBO J. 29 3344-57 PubMed GONUTS page