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DROME:SMSR1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) SMSr
Protein Name(s) Sphingomyelin synthase-related 1

Ceramide phosphoethanolamine synthase CPE synthase

External Links
UniProt Q9VS60
EMBL AE014296
AE014296
AY051605
BT003174
RefSeq NP_648114.1
UniGene Dm.874
ProteinModelPortal Q9VS60
BioGrid 64262
MINT MINT-1647866
STRING 7227.FBpp0076580
PaxDb Q9VS60
EnsemblMetazoa FBtr0076870
GeneID 38823
KEGG dme:Dmel_CG32380
UCSC CG32380-RA
CTD 38823
FlyBase FBgn0052380
eggNOG NOG259509
GeneTree ENSGT00390000001630
InParanoid Q9VS60
OMA RAYRIWS
OrthoDB EOG7NCV32
PhylomeDB Q9VS60
BioCyc FLY:FBGN0052380-MONOMER
ChiTaRS SMSr
GenomeRNAi 38823
NextBio 810560
PRO PR:Q9VS60
Proteomes UP000000803
Bgee Q9VS60
GO GO:0030176
GO:0016021
GO:0047493
GO:0033188
GO:0046513
GO:0007030
GO:0060305
GO:2000303
GO:0006686
Gene3D 1.10.150.50
InterPro IPR001660
IPR013761
IPR025749
Pfam PF14360
SUPFAM SSF47769
PROSITE PS50105

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0006629

lipid metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

GO:0006665

sphingolipid metabolic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0746

P

Seeded From UniProt

complete

GO:0006686

sphingomyelin biosynthetic process

PMID:14685263[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007030

Golgi organization

PMID:21383842[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:14685263[1]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0030176

integral component of endoplasmic reticulum membrane

PMID:19506037[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0033188

sphingomyelin synthase activity

PMID:19506037[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0046513

ceramide biosynthetic process

PMID:19506037[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0047493

ceramide cholinephosphotransferase activity

PMID:19506037[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0060305

regulation of cell diameter

PMID:21383842[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000303

regulation of ceramide biosynthetic process

PMID:19506037[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Huitema, K et al. (2004) Identification of a family of animal sphingomyelin synthases. EMBO J. 23 33-44 PubMed GONUTS page
  2. 2.0 2.1 Kondylis, V et al. (2011) Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PLoS ONE 6 e17173 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Vacaru, AM et al. (2009) Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J. Cell Biol. 185 1013-27 PubMed GONUTS page