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DROME:Q94544

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) Phosphatidylinositol 4-phosphate 5-kinase (ECO:0000313 with EMBL:AAC25576.1)
External Links
UniProt Q94544
EMBL AF071417
ProteinModelPortal Q94544
STRING 7227.FBpp0071491
FlyBase FBgn0016984
Reactome REACT_180738
REACT_232187
REACT_251367
Bgee Q94544
ExpressionAtlas Q94544
GO GO:0005938
GO:0035323
GO:0005634
GO:0005886
GO:0016308
GO:0048102
GO:0034613
GO:0030866
GO:0042070
GO:0008103
GO:0007422
GO:0046854
GO:0016310
GO:0035071
GO:0007286
Gene3D 3.30.800.10
3.30.810.10
InterPro IPR023610
IPR027483
IPR002498
IPR027484
IPR016034
PANTHER PTHR23086
Pfam PF01504
SMART SM00330
PROSITE PS51455

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030010

establishment of cell polarity

PMID:20237161[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3

complete
CACAO 2024

Colocalizes with

GO:0000145

exocyst

PMID:20237161[1]

IMP: Inferred from Mutant Phenotype

C

Figure 5, Figure 6

complete
CACAO 2038

GO:0005634

nucleus

PMID:11102367[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:20237161[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:18948416[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007286

spermatid development

PMID:20237161[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

PMID:11102367[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008103

oocyte microtubule cytoskeleton polarization

PMID:18948416[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016307

phosphatidylinositol phosphate kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002498

F

Seeded From UniProt

complete

GO:0016308

1-phosphatidylinositol-4-phosphate 5-kinase activity

PMID:10908587[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0016308

1-phosphatidylinositol-4-phosphate 5-kinase activity

PMID:11102367[2]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0016308

1-phosphatidylinositol-4-phosphate 5-kinase activity

PMID:24768049[5]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

PMID:10908587[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0030010

establishment of cell polarity

PMID:20237161[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030866

cortical actin cytoskeleton organization

PMID:18948416[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034613

cellular protein localization

PMID:23853710[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:12593804[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0035323

male germline ring canal

PMID:20237161[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042070

maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification

PMID:18948416[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002498

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002498

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:10908587[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:11102367[2]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:24768049[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048102

autophagic cell death

PMID:12593804[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0071711

basement membrane organization

PMID:24828534[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

colocalizes_with

GO:0000145

exocyst

PMID:20237161[1]

IMP: Inferred from Mutant Phenotype

C

Seeded From UniProt

complete

colocalizes_with

GO:0016324

apical plasma membrane

PMID:23853710[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fabian, L et al. (2010) Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila. Mol. Biol. Cell 21 1546-55 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Prokopenko, SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156 1691-715 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gervais, L et al. (2008) PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte. Development 135 3829-38 PubMed GONUTS page
  4. 4.0 4.1 4.2 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  5. 5.0 5.1 Claret, S et al. (2014) PI(4,5)P2 produced by the PI4P5K SKTL controls apical size by tethering PAR-3 in Drosophila epithelial cells. Curr. Biol. 24 1071-9 PubMed GONUTS page
  6. 6.0 6.1 Rousso, T et al. (2013) Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife 2 e00666 PubMed GONUTS page
  7. 7.0 7.1 Gorski, SM et al. (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr. Biol. 13 358-63 PubMed GONUTS page
  8. Devergne, O et al. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 111 7689-94 PubMed GONUTS page