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DROME:Q94544

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) Phosphatidylinositol 4-phosphate 5-kinase (ECO:0000313 with EMBL:AAC25576.1)
External Links
UniProt Q94544
EMBL AF071417
ProteinModelPortal Q94544
STRING 7227.FBpp0071491
FlyBase FBgn0016984
Reactome REACT_180738
REACT_232187
REACT_251367
Bgee Q94544
ExpressionAtlas Q94544
GO GO:0005938
GO:0035323
GO:0005634
GO:0005886
GO:0016308
GO:0048102
GO:0034613
GO:0030866
GO:0042070
GO:0008103
GO:0007422
GO:0046854
GO:0016310
GO:0035071
GO:0007286
Gene3D 3.30.800.10
3.30.810.10
InterPro IPR023610
IPR027483
IPR002498
IPR027484
IPR016034
PANTHER PTHR23086
Pfam PF01504
SMART SM00330
PROSITE PS51455

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030010

establishment of cell polarity

PMID:20237161[1]

ECO:0000315

P

Figure 3

complete
CACAO 2024

GO:0000145

exocyst

PMID:20237161[1]

ECO:0000315

C

Figure 5, Figure 6

complete
CACAO 2038

involved_in

GO:0033128

negative regulation of histone phosphorylation

PMID:15280236[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001044)

Seeded From UniProt

complete

part_of

GO:0005700

polytene chromosome

PMID:15280236[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q94545

C

part_of:(UBERON:0001044)

Seeded From UniProt

complete

part_of

GO:0000145

exocyst

PMID:20237161[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030010

establishment of cell polarity

PMID:20237161[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007310

oocyte dorsal/ventral axis specification

PMID:18948416[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030866

cortical actin cytoskeleton organization

PMID:18948416[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016308

1-phosphatidylinositol-4-phosphate 5-kinase activity

PMID:10908587[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

PMID:10908587[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071711

basement membrane organization

PMID:24828534[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016308

1-phosphatidylinositol-4-phosphate 5-kinase activity

PMID:24768049[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034613

cellular protein localization

PMID:23853710[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0016324

apical plasma membrane

PMID:23853710[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035323

male germline ring canal

PMID:20237161[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:20237161[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007286

spermatid development

PMID:20237161[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:18948416[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008103

oocyte microtubule cytoskeleton polarization

PMID:18948416[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016307

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016307

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016308

P

Seeded From UniProt

complete

involved_in

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016308

P

Seeded From UniProt

complete

enables

GO:0016307

phosphatidylinositol phosphate kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002498

F

Seeded From UniProt

complete

involved_in

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002498

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016307

phosphatidylinositol phosphate kinase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

F

Seeded From UniProt

complete

involved_in

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400519

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Fabian, L et al. (2010) Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila. Mol. Biol. Cell 21 1546-55 PubMed GONUTS page
  2. 2.0 2.1 Cheng, MK & Shearn, A (2004) The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin. Genetics 167 1213-23 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gervais, L et al. (2008) PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte. Development 135 3829-38 PubMed GONUTS page
  4. 4.0 4.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  5. Devergne, O et al. (2014) Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A. 111 7689-94 PubMed GONUTS page
  6. Claret, S et al. (2014) PI(4,5)P2 produced by the PI4P5K SKTL controls apical size by tethering PAR-3 in Drosophila epithelial cells. Curr. Biol. 24 1071-9 PubMed GONUTS page
  7. 7.0 7.1 Rousso, T et al. (2013) Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife 2 e00666 PubMed GONUTS page