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DROME:Q3KN41

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) LP14275p (ECO:0000313 with EMBL:ABA81832.1)

Neurexin 1, isoform B (ECO:0000313 with EMBL:ACZ94983.1)

External Links
UniProt Q3KN41
EMBL BT023898
AE014297
RefSeq NP_001163687.1
NP_001262838.1
NP_001262842.1
UniGene Dm.1980
EnsemblMetazoa FBtr0301485
GeneID 42646
KEGG dme:Dmel_CG7050
CTD 42646
FlyBase FBgn0038975
GeneTree ENSGT00760000118991
OMA RFRGAIR
OrthoDB EOG7XWPMM
Reactome REACT_184374
ChiTaRS Nrx-1
GenomeRNAi 42646
NextBio 829856
Proteomes UP000000803
GO GO:0016021
GO:0031594
GO:0005886
GO:0034185
GO:0046872
GO:0097109
GO:0008306
GO:0007274
GO:1900244
GO:0040012
GO:1900073
GO:2000331
GO:0007416
GO:0050808
GO:0051124
GO:0007268
GO:0071938
Gene3D 2.60.120.200
InterPro IPR013320
IPR000742
IPR001791
IPR027160
PANTHER PTHR10127:SF593
Pfam PF00008
PF02210
SMART SM00181
SM00282
SUPFAM SSF49899
PROSITE PS50026
PS50025

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0061174

type I terminal button

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

C

Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction. Overexpression of DNRX showed correct localization at glutamatergic type I boutons of the larval body wall muscles (Bb–b”) Same as wildtype Bc and Bd). Similar result seen in figure 4 Ba, Bc, Bd.

complete
CACAO 3179

GO:0031594

neuromuscular junction

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction.

complete
CACAO 3180

GO:0040011

locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5C DNRX deficient larvae showed severe defect in locomotion compared to wild type.

complete
CACAO 3181

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5Ac and B showed 49% decrease in bouton number at neuromuscular junction in mutant dnrx fly compared to wild type.

complete
CACAO 3182

GO:0048488

synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Synaptic vesicle recycling was measured using FM1-43 dye. Figure 6Ac and B showed reduction in dye uptake in mutant dnrx fly.

complete
CACAO 3183

GO:0007274

neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Intracellular recoding at neuromuscular junction Figure 7 BC, shows decrease in amplitude excitatory potential of Dnrx mutant flies.

complete
CACAO 3184

GO:0005515

protein binding

PMID:19379781[1]

IPI: Inferred from Physical Interaction

FB:FBgn0013759

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20462449[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007268

synaptic transmission

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027160

P

Seeded From UniProt

complete

GO:0007268

synaptic transmission

PMID:17785181[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:23136438[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007416

synapse assembly

PMID:17498701[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008306

associative learning

PMID:17498701[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027160

C

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:20559439[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0034185

apolipoprotein binding

PMID:23352167[7]

IPI: Inferred from Physical Interaction

FB:FBgn0087002

F

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040012

regulation of locomotion

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0013759

P

Seeded From UniProt

complete

GO:0040012

regulation of locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027160

F

Seeded From UniProt

complete

GO:0048488

synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050808

synapse organization

PMID:17785181[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0051124

synaptic growth at neuromuscular junction

PMID:23136438[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0061174

type I terminal bouton

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

C

Seeded From UniProt

complete

GO:0071938

vitamin A transport

PMID:23352167[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0097109

neuroligin family protein binding

PMID:23136438[4]

IPI: Inferred from Physical Interaction

FB:FBgn0031866

F

Seeded From UniProt

complete

GO:1900073

regulation of neuromuscular synaptic transmission

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0013759

P

Seeded From UniProt

complete

GO:1900073

regulation of neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900244

positive regulation of synaptic vesicle endocytosis

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0013759

P

Seeded From UniProt

complete

GO:1900244

positive regulation of synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 Sun, M et al. (2009) Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci. Res. 64 362-71 PubMed GONUTS page
  2. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  3. 3.0 3.1 Li, J et al. (2007) Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron 55 741-55 PubMed GONUTS page
  4. 4.0 4.1 4.2 Chen, YC et al. (2012) Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J. Neurosci. 32 16018-30 PubMed GONUTS page
  5. 5.0 5.1 Zeng, X et al. (2007) Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett. 581 2509-16 PubMed GONUTS page
  6. Chen, K et al. (2010) Neurexin in embryonic Drosophila neuromuscular junctions. PLoS ONE 5 e11115 PubMed GONUTS page
  7. 7.0 7.1 Tian, Y et al. (2013) Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron 77 311-22 PubMed GONUTS page