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DROME:Q3KN41
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | LP14275p (ECO:0000313 with EMBL:ABA81832.1)
Neurexin 1, isoform B (ECO:0000313 with EMBL:ACZ94983.1) | |
| External Links | ||
| UniProt | Q3KN41 | |
| EMBL | BT023898 AE014297 | |
| RefSeq | NP_001163687.1 NP_001262838.1 NP_001262842.1 | |
| UniGene | Dm.1980 | |
| EnsemblMetazoa | FBtr0301485 | |
| GeneID | 42646 | |
| KEGG | dme:Dmel_CG7050 | |
| CTD | 42646 | |
| FlyBase | FBgn0038975 | |
| GeneTree | ENSGT00760000118991 | |
| OMA | RFRGAIR | |
| OrthoDB | EOG7XWPMM | |
| Reactome | REACT_184374 | |
| ChiTaRS | Nrx-1 | |
| GenomeRNAi | 42646 | |
| NextBio | 829856 | |
| Proteomes | UP000000803 | |
| GO | GO:0016021 GO:0031594 GO:0005886 GO:0034185 GO:0046872 GO:0097109 GO:0008306 GO:0007274 GO:1900244 GO:0040012 GO:1900073 GO:2000331 GO:0007416 GO:0050808 GO:0051124 GO:0007268 GO:0071938 | |
| Gene3D | 2.60.120.200 | |
| InterPro | IPR013320 IPR000742 IPR001791 IPR027160 | |
| PANTHER | PTHR10127:SF593 | |
| Pfam | PF00008 PF02210 | |
| SMART | SM00181 SM00282 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50026 PS50025 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0061174 |
type I terminal button |
ECO:0000315 |
C |
Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction. Overexpression of DNRX showed correct localization at glutamatergic type I boutons of the larval body wall muscles (Bb–b”) Same as wildtype Bc and Bd). Similar result seen in figure 4 Ba, Bc, Bd. |
complete | |||||
| GO:0031594 |
neuromuscular junction |
ECO:0000314 |
C |
Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction. |
complete | |||||
| GO:0040011 |
locomotion |
ECO:0000315 |
P |
Figure 5C DNRX deficient larvae showed severe defect in locomotion compared to wild type. |
complete | |||||
| GO:2000331 |
regulation of terminal button organization |
ECO:0000315 |
P |
Figure 5Ac and B showed 49% decrease in bouton number at neuromuscular junction in mutant dnrx fly compared to wild type. |
complete | |||||
| GO:0048488 |
synaptic vesicle endocytosis |
ECO:0000315 |
P |
Synaptic vesicle recycling was measured using FM1-43 dye. Figure 6Ac and B showed reduction in dye uptake in mutant dnrx fly. |
complete | |||||
| GO:0007274 |
neuromuscular synaptic transmission |
ECO:0000315 |
P |
Intracellular recoding at neuromuscular junction Figure 7 BC, shows decrease in amplitude excitatory potential of Dnrx mutant flies. |
complete | |||||
|
involved_in |
GO:0007274 |
neuromuscular synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048488 |
synaptic vesicle endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000331 |
regulation of terminal button organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040011 |
locomotion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031594 |
neuromuscular junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0061174 |
type I terminal bouton |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071938 |
vitamin A transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034185 |
apolipoprotein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0087002 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0097109 |
neuroligin family protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0031866 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007274 |
neuromuscular synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051124 |
synaptic growth at neuromuscular junction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900244 |
positive regulation of synaptic vesicle endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900244 |
positive regulation of synaptic vesicle endocytosis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0013759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0040012 |
regulation of locomotion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0013759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000331 |
regulation of terminal button organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900073 |
regulation of neuromuscular synaptic transmission |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0013759 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0040012 |
regulation of locomotion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900073 |
regulation of neuromuscular synaptic transmission |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031594 |
neuromuscular junction |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007416 |
synapse assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008306 |
associative learning |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050808 |
synapse organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 Sun, M et al. (2009) Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci. Res. 64 362-71 PubMed GONUTS page
- ↑ 2.0 2.1 Li, J et al. (2007) Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron 55 741-55 PubMed GONUTS page
- ↑ 3.0 3.1 Tian, Y et al. (2013) Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron 77 311-22 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Chen, YC et al. (2012) Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J. Neurosci. 32 16018-30 PubMed GONUTS page
- ↑ Chen, K et al. (2010) Neurexin in embryonic Drosophila neuromuscular junctions. PLoS ONE 5 e11115 PubMed GONUTS page
- ↑ 6.0 6.1 Zeng, X et al. (2007) Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett. 581 2509-16 PubMed GONUTS page
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