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DROME:PLU

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) plu
Protein Name(s) DNA replication inhibitor plutonium
External Links
UniProt P42570
EMBL U03986
AE013599
PIR S41713
RefSeq NP_476683.1
ProteinModelPortal P42570
SMR P42570
BioGrid 69325
DIP DIP-24015N
IntAct P42570
MINT MINT-769934
PRIDE P42570
EnsemblMetazoa FBtr0086306
GeneID 44848
KEGG dme:Dmel_CG9183
UCSC CG9183-RA
CTD 44848
FlyBase FBgn0003114
eggNOG NOG240093
InParanoid P42570
OMA NYFGQNA
OrthoDB EOG7M3J1N
PhylomeDB P42570
SignaLink P42570
GenomeRNAi 44848
NextBio 837719
Proteomes UP000000803
Bgee P42570
ExpressionAtlas P42570
GO GO:0006260
GO:0007343
GO:0008156
GO:0007346
GO:0007338
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
Pfam PF00023
SMART SM00248
SUPFAM SSF48403
PROSITE PS50297
PS50088

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0045977

positive regulation of mitotic cell cycle, embryonic

PMID:11044392[1]

IDA: Inferred from Direct Assay

P

See Figure 5B. Co-expressor with PNG.

complete
CACAO 5078

GO:0045977

positive regulation of mitotic cell cycle, embryonic

PMID:11044392[1]

IMP: Inferred from Mutant Phenotype

P

See the comparisons of the mutant and wild-type genotypes in figure 7.

complete
CACAO 5190

GO:0006260

DNA replication

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0235

P

Seeded From UniProt

complete

GO:0007338

single fertilization

PMID:8313891[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007343

egg activation

PMID:12871909[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007346

regulation of mitotic cell cycle

PMID:14616073[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008156

negative regulation of DNA replication

PMID:8313891[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1902554

serine/threonine protein kinase complex

PMID:11044392[1]

IPI: Inferred from Physical Interaction

FB:FBgn0000826

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Fenger, DD et al. (2000) PAN GU: a protein kinase that inhibits S phase and promotes mitosis in early Drosophila development. Development 127 4763-74 PubMed GONUTS page
  2. 2.0 2.1 Axton, JM et al. (1994) The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. EMBO J. 13 462-70 PubMed GONUTS page
  3. Tadros, W et al. (2003) Regulation of maternal transcript destabilization during egg activation in Drosophila. Genetics 164 989-1001 PubMed GONUTS page
  4. Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page