GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
DROME:PGAM5
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Pgam5 | |
| Protein Name(s) | Serine/threonine-protein phosphatase Pgam5, mitochondrial
DPGAM5 Phosphoglycerate mutase family member 5 homolog | |
| External Links | ||
| UniProt | O46084 | |
| EMBL | AE014298 AL021106 AY060608 | |
| PIR | T12682 | |
| RefSeq | NP_569951.1 | |
| ProteinModelPortal | O46084 | |
| SMR | O46084 | |
| BioGrid | 57689 | |
| DIP | DIP-18549N | |
| IntAct | O46084 | |
| MINT | MINT-928929 | |
| STRING | 7227.FBpp0070350 | |
| PaxDb | O46084 | |
| PRIDE | O46084 | |
| EnsemblMetazoa | FBtr0070366 | |
| GeneID | 31143 | |
| KEGG | dme:Dmel_CG14816 | |
| UCSC | CG14816-RA | |
| CTD | 192111 | |
| FlyBase | FBgn0023517 | |
| eggNOG | NOG71348 | |
| GeneTree | ENSGT00390000004796 | |
| InParanoid | O46084 | |
| KO | K15637 | |
| OMA | EIIVCHA | |
| OrthoDB | EOG7966H1 | |
| PhylomeDB | O46084 | |
| GenomeRNAi | 31143 | |
| NextBio | 772127 | |
| Proteomes | UP000000803 | |
| Bgee | O46084 | |
| GO | GO:0016021 GO:0005741 GO:0005739 GO:0019900 GO:0004721 GO:0043539 GO:0035970 GO:0090141 GO:0071902 GO:0006470 GO:0010821 GO:0072347 GO:0009408 | |
| Gene3D | 3.40.50.1240 | |
| InterPro | IPR013078 IPR029033 | |
| Pfam | PF00300 | |
| SMART | SM00855 | |
| SUPFAM | SSF53254 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0019900 |
kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004722 |
protein serine/threonine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0004619 |
phosphoglycerate mutase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043539 |
protein serine/threonine kinase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035970 |
peptidyl-threonine dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0009408 |
response to heat |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010821 |
regulation of mitochondrion organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010821 |
regulation of mitochondrion organization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0029891 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090141 |
positive regulation of mitochondrial fission |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072347 |
response to anesthetic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0043539 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Takeda, K et al. (2009) Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 12301-5 PubMed GONUTS page
- ↑ Ishida, Y et al. (2012) Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. PLoS ONE 7 e30265 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Imai, Y et al. (2010) The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet. 6 e1001229 PubMed GONUTS page
- ↑ Campbell, JL et al. (2009) Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. J. Neurogenet. 23 412-21 PubMed GONUTS page
m
n
p
- GO:0035970 ! peptidyl-threonine dephosphorylation
- GO:0004619 ! phosphoglycerate mutase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0071902 ! positive regulation of protein serine/threonine kinase activity
- GO:0090141 ! positive regulation of mitochondrial fission
- GO:0006470 ! protein dephosphorylation
- GO:0043539 ! protein serine/threonine kinase activator activity
- GO:0004722 ! protein serine/threonine phosphatase activity
- Pterygota
r
