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DROME:PGAM5

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Pgam5
Protein Name(s) Serine/threonine-protein phosphatase Pgam5, mitochondrial

DPGAM5 Phosphoglycerate mutase family member 5 homolog

External Links
UniProt O46084
EMBL AE014298
AL021106
AY060608
PIR T12682
RefSeq NP_569951.1
ProteinModelPortal O46084
SMR O46084
BioGrid 57689
DIP DIP-18549N
IntAct O46084
MINT MINT-928929
STRING 7227.FBpp0070350
PaxDb O46084
PRIDE O46084
EnsemblMetazoa FBtr0070366
GeneID 31143
KEGG dme:Dmel_CG14816
UCSC CG14816-RA
CTD 192111
FlyBase FBgn0023517
eggNOG NOG71348
GeneTree ENSGT00390000004796
InParanoid O46084
KO K15637
OMA EIIVCHA
OrthoDB EOG7966H1
PhylomeDB O46084
GenomeRNAi 31143
NextBio 772127
Proteomes UP000000803
Bgee O46084
GO GO:0016021
GO:0005741
GO:0005739
GO:0019900
GO:0004721
GO:0043539
GO:0035970
GO:0090141
GO:0071902
GO:0006470
GO:0010821
GO:0072347
GO:0009408
Gene3D 3.40.50.1240
InterPro IPR013078
IPR029033
Pfam PF00300
SMART SM00855
SUPFAM SSF53254

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.16

F

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

PMID:19590015[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

PMID:19590015[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21151955[2]

IPI: Inferred from Physical Interaction

FB:FBgn0029891

F

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:19590015[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96HS1

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1000

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

PMID:19590015[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0009408

response to heat

PMID:22347370[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010821

regulation of mitochondrion organization

PMID:21151955[2]

IGI: Inferred from Genetic Interaction

FB:FBgn0029891

P

Seeded From UniProt

complete

GO:0010821

regulation of mitochondrion organization

PMID:21151955[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

PMID:19590015[1]

ISM: Inferred from Sequence Model

C

Seeded From UniProt

Missing: with/from

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0019900

kinase binding

PMID:19590015[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q24458

F

Seeded From UniProt

complete

GO:0035970

peptidyl-threonine dephosphorylation

PMID:19590015[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043539

protein serine/threonine kinase activator activity

PMID:19590015[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0071902

positive regulation of protein serine/threonine kinase activity

PMID:19590015[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0072347

response to anesthetic

PMID:19863272[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0090141

positive regulation of mitochondrial fission

PMID:21151955[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Takeda, K et al. (2009) Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 12301-5 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Imai, Y et al. (2010) The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet. 6 e1001229 PubMed GONUTS page
  3. Ishida, Y et al. (2012) Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. PLoS ONE 7 e30265 PubMed GONUTS page
  4. Campbell, JL et al. (2009) Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. J. Neurogenet. 23 412-21 PubMed GONUTS page