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DROME:OFUT2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) O-fut2
Protein Name(s) GDP-fucose protein O-fucosyltransferase 2

Peptide-O-fucosyltransferase 2 O-FucT-2

External Links
UniProt Q9W589
EMBL AE014298
AL031027
AL035632
AY047568
RefSeq NP_569916.1
SMR Q9W589
BioGrid 57655
IntAct Q9W589
STRING 7227.FBpp0070283
CAZy GT68
PaxDb Q9W589
PRIDE Q9W589
EnsemblMetazoa FBtr0070296
GeneID 31098
KEGG dme:Dmel_CG14789
CTD 31098
FlyBase FBgn0027791
eggNOG ENOG410IFPR
ENOG410Y78N
GeneTree ENSGT00390000007989
InParanoid Q9W589
KO K03691
OMA YILYDVN
OrthoDB 654070at2759
PhylomeDB Q9W589
Reactome R-DME-5173214
UniPathway UPA00378
GenomeRNAi 31098
PRO PR:Q9W589
Proteomes UP000000803
Bgee FBgn0027791
Genevisible Q9W589
GO GO:0005783
GO:0005794
GO:0046922
GO:0006004
GO:0016266
GO:0006355
InterPro IPR019378
Pfam PF10250

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

involved_in

GO:0016266

O-glycan processing

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:11698403[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0027791
PANTHER:PTN000333762
UniProtKB:Q9Y2G5

F

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.221

F

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:11698403[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

involved_in

GO:0016266

O-glycan processing

PMID:11698403[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

involved_in

GO:0006004

fucose metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0294

P

Seeded From UniProt

involved_in

GO:0006486

protein glycosylation

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00378

P

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:11698403[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

involved_in

GO:0016266

O-glycan processing

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

involved_in

GO:0016266

O-glycan processing

PMID:11698403[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:11698403[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

PMID:16464857[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0027791
PANTHER:PTN000333762
UniProtKB:Q9Y2G5

F

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

involved_in

GO:0036066

protein O-linked fucosylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0046922

P

Seeded From UniProt

enables

GO:0046922

peptide-O-fucosyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.1.221

F

Seeded From UniProt

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256
UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

involved_in

GO:0006004

fucose metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0294

P

Seeded From UniProt

part_of

GO:0005794

Golgi apparatus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0095

C

Seeded From UniProt

GO:0036066

protein O-linked fucosylation

PMID:16464857[1]

ECO:0006052

RNAi evidence used in manual assertion

P

Fig. 2 shows that the RNAi knockdown of the Ofut2 reduces the TSR O-fucosyltransferase activity in Drosophila melanogaster (Fruit fly) S2 cells. Uniport: GDP-fucose protein O-fucosyltransferase 2.

complete

involved_in

GO:0006486

protein glycosylation

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00378

P

Seeded From UniProt

GO:0046922

peptide-O-fucosyltransferase activity

PMID:16464857[1]

ECO:0007846

radioisotope quantification assay evidence used in manual assertion

F

Fig. 4 shows that recombinant OFUT2 transfers fucose to TSP1-TSR3 in O-linkage using gel filtration chromatography and high-pH anion exchange chromatography Uniport: GDP-fucose protein O-fucosyltransferase 2 Organism: Drosophila melanogaster (Fruit fly)

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Luo, Y et al. (2006) Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats. J. Biol. Chem. 281 9393-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Roos, C et al. (2002) Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. J. Biol. Chem. 277 3168-75 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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