DROME:CTNA

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	alpha-Cat
Protein Name(s)	Catenin alpha
External Links
UniProt	P35220
EMBL	D13964 AE014296 AY051780
PIR	A40694
RefSeq	NP_524219.1
UniGene	Dm.7158
ProteinModelPortal	P35220
SMR	P35220
BioGrid	65744
DIP	DIP-21662N
IntAct	P35220
MINT	MINT-769048
PaxDb	P35220
PRIDE	P35220
EnsemblMetazoa	FBtr0070038
GeneID	40517
KEGG	dme:Dmel_CG17947
CTD	40517
FlyBase	FBgn0010215
eggNOG	NOG240050
GeneTree	ENSGT00550000074411
InParanoid	P35220
KO	K05691
OMA	MVRAARN
OrthoDB	EOG7HQN7B
PhylomeDB	P35220
Reactome	REACT_209888 REACT_236156 REACT_246045
ChiTaRS	alpha-Cat
GenomeRNAi	40517
NextBio	819161
PRO	PR:P35220
Proteomes	UP000000803
Bgee	P35220
ExpressionAtlas	P35220
GO	GO:0015629 GO:0005912 GO:0016342 GO:0005913 GO:0005737 GO:0005886 GO:0005914 GO:0005915 GO:0003779 GO:0008092 GO:0005198 GO:0034332 GO:0007155 GO:0007016 GO:0060429 GO:0007163 GO:0030727 GO:0060323 GO:0030720
InterPro	IPR001033 IPR006077 IPR000633
PANTHER	PTHR18914
Pfam	PF01044
PRINTS	PR00805
SUPFAM	SSF47220
PROSITE	PS00663

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0042802	identical protein binding	PMID:23417122^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35220	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25294944^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:25294943^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19317464^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	PMID:23417122^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22595515^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	PMID:22266901^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060323	head morphogenesis	PMID:22266901^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	PMID:18636970^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18636970^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:16399083^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:12766944^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12766944^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005915	zonula adherens	PMID:12530954^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005914	spot adherens junction	PMID:12231350^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	PMID:12147138^[12]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008092	cytoskeletal protein binding	PMID:10908588^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
enables	GO:0003779	actin binding	PMID:10908588^[13]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
involved_in	GO:0007016	cytoskeletal anchoring at plasma membrane	PMID:10908592^[14]	ECO:0000250	sequence similarity evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
part_of	GO:0016342	catenin complex	PMID:10908592^[14]	ECO:0000250	sequence similarity evidence used in manual assertion		C		Seeded From UniProt	Missing: with/from
part_of	GO:0005886	plasma membrane	PMID:27831494^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	PMID:27831494^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0046664)	Seeded From UniProt	complete
involved_in	GO:0003383	apical constriction	PMID:27831494^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0046664)	Seeded From UniProt	complete
involved_in	GO:0046664	dorsal closure, amnioserosa morphology change	PMID:27831494^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000633	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000633 InterPro:IPR001033 InterPro:IPR006077 InterPro:IPR036723	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000633	C		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001033	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001033 InterPro:IPR006077 InterPro:IPR036723	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005912	adherens junction	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0009	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Desai, R et al. (2013) Monomeric α-catenin links cadherin to the actin cytoskeleton. Nat. Cell Biol. 15 261-73 PubMed GONUTS page
↑ Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
↑ Lowe, N et al. (2014) Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development 141 3994-4005 PubMed GONUTS page
↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
↑ Dottermusch-Heidel, C et al. (2012) The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. Dev. Biol. 368 18-27 PubMed GONUTS page
↑ ^6.0 ^6.1 Sarpal, R et al. (2012) Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function. J. Cell. Sci. 125 233-45 PubMed GONUTS page
↑ ^7.0 ^7.1 Menzel, N et al. (2008) The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo. Biochem. J. 416 231-41 PubMed GONUTS page
↑ Wang, H et al. (2006) Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev. Cell 10 117-26 PubMed GONUTS page
↑ ^9.0 ^9.1 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
↑ Müller, HA (2003) Epithelial polarity in flies: more than just crumbs. Dev. Cell 4 1-3 PubMed GONUTS page
↑ Wedlich, D (2002) The polarising role of cell adhesion molecules in early development. Curr. Opin. Cell Biol. 14 563-8 PubMed GONUTS page
↑ Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
↑ ^13.0 ^13.1 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Jurado, J et al. (2016) α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. J. Cell. Sci. 129 4496-4508 PubMed GONUTS page

[PMID:23417122-1] 1.0 ^1.1 Desai, R et al. (2013) Monomeric α-catenin links cadherin to the actin cytoskeleton. Nat. Cell Biol. 15 261-73 PubMed GONUTS page

[PMID:25294944-2] Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page

[PMID:25294943-3] Lowe, N et al. (2014) Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development 141 3994-4005 PubMed GONUTS page

[PMID:19317464-4] Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page

[PMID:22595515-5] Dottermusch-Heidel, C et al. (2012) The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. Dev. Biol. 368 18-27 PubMed GONUTS page

[PMID:22266901-6] 6.0 ^6.1 Sarpal, R et al. (2012) Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function. J. Cell. Sci. 125 233-45 PubMed GONUTS page

[PMID:18636970-7] 7.0 ^7.1 Menzel, N et al. (2008) The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo. Biochem. J. 416 231-41 PubMed GONUTS page

[PMID:16399083-8] Wang, H et al. (2006) Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev. Cell 10 117-26 PubMed GONUTS page

[PMID:12766944-9] 9.0 ^9.1 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page

[PMID:12530954-10] Müller, HA (2003) Epithelial polarity in flies: more than just crumbs. Dev. Cell 4 1-3 PubMed GONUTS page

[PMID:12231350-11] Wedlich, D (2002) The polarising role of cell adhesion molecules in early development. Curr. Opin. Cell Biol. 14 563-8 PubMed GONUTS page

[PMID:12147138-12] Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page

[PMID:10908588-13] 13.0 ^13.1 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page

[PMID:10908592-14] 14.0 ^14.1 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page

[PMID:27831494-15] 15.0 ^15.1 ^15.2 ^15.3 Jurado, J et al. (2016) α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. J. Cell. Sci. 129 4496-4508 PubMed GONUTS page

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DROME:CTNA

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