GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:CTNA

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) alpha-Cat
Protein Name(s) Catenin alpha
External Links
UniProt P35220
EMBL D13964
AE014296
AY051780
PIR A40694
RefSeq NP_524219.1
UniGene Dm.7158
ProteinModelPortal P35220
SMR P35220
BioGrid 65744
DIP DIP-21662N
IntAct P35220
MINT MINT-769048
PaxDb P35220
PRIDE P35220
EnsemblMetazoa FBtr0070038
GeneID 40517
KEGG dme:Dmel_CG17947
CTD 40517
FlyBase FBgn0010215
eggNOG NOG240050
GeneTree ENSGT00550000074411
InParanoid P35220
KO K05691
OMA MVRAARN
OrthoDB EOG7HQN7B
PhylomeDB P35220
Reactome REACT_209888
REACT_236156
REACT_246045
ChiTaRS alpha-Cat
GenomeRNAi 40517
NextBio 819161
PRO PR:P35220
Proteomes UP000000803
Bgee P35220
ExpressionAtlas P35220
GO GO:0015629
GO:0005912
GO:0016342
GO:0005913
GO:0005737
GO:0005886
GO:0005914
GO:0005915
GO:0003779
GO:0008092
GO:0005198
GO:0034332
GO:0007155
GO:0007016
GO:0060429
GO:0007163
GO:0030727
GO:0060323
GO:0030720
InterPro IPR001033
IPR006077
IPR000633
PANTHER PTHR18914
Pfam PF01044
PRINTS PR00805
SUPFAM SSF47220
PROSITE PS00663

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003779

actin binding

PMID:10908588[1]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005198

structural molecule activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000633

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9635189[2]

IPI: Inferred from Physical Interaction

UniProtKB:P18824-2

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:18636970[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:19317464[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20462449[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:22595515[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:25294944[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005912

adherens junction

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0009

C

Seeded From UniProt

complete

GO:0005912

adherens junction

PMID:12147138[8]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005912

adherens junction

PMID:12766944[9]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005912

adherens junction

PMID:25294943[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005913

cell-cell adherens junction

PMID:16399083[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005914

spot adherens junction

PMID:12231350[12]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005915

zonula adherens

PMID:12530954[13]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0007016

cytoskeletal anchoring at plasma membrane

PMID:10908592[14]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0007155

cell adhesion

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000633
InterPro:IPR001033
InterPro:IPR006077

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007163

establishment or maintenance of cell polarity

PMID:12766944[9]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007293

germarium-derived egg chamber formation

PMID:24762813[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008092

cytoskeletal protein binding

PMID:10908588[1]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0015629

actin cytoskeleton

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000633

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016342

catenin complex

PMID:10908592[14]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0016342

catenin complex

PMID:18636970[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030054

cell junction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

GO:0030054

cell junction

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0038

C

Seeded From UniProt

complete

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

PMID:11131529[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0034332

adherens junction organization

PMID:22266901[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034332

adherens junction organization

PMID:23417122[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045296

cadherin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001033

F

Seeded From UniProt

complete

GO:0051015

actin filament binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001033
InterPro:IPR006077

F

Seeded From UniProt

complete

GO:0060323

head morphogenesis

PMID:22266901[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060429

epithelium development

PMID:24762813[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  2. Loureiro, J & Peifer, M (1998) Roles of Armadillo, a Drosophila catenin, during central nervous system development. Curr. Biol. 8 622-32 PubMed GONUTS page
  3. 3.0 3.1 Menzel, N et al. (2008) The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo. Biochem. J. 416 231-41 PubMed GONUTS page
  4. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  5. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  6. Dottermusch-Heidel, C et al. (2012) The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. Dev. Biol. 368 18-27 PubMed GONUTS page
  7. Lye, CM et al. (2014) Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. Development 141 4006-17 PubMed GONUTS page
  8. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  9. 9.0 9.1 Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
  10. Lowe, N et al. (2014) Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development 141 3994-4005 PubMed GONUTS page
  11. Wang, H et al. (2006) Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev. Cell 10 117-26 PubMed GONUTS page
  12. Wedlich, D (2002) The polarising role of cell adhesion molecules in early development. Curr. Opin. Cell Biol. 14 563-8 PubMed GONUTS page
  13. Müller, HA (2003) Epithelial polarity in flies: more than just crumbs. Dev. Cell 4 1-3 PubMed GONUTS page
  14. 14.0 14.1 Hynes, RO & Zhao, Q (2000) The evolution of cell adhesion. J. Cell Biol. 150 F89-96 PubMed GONUTS page
  15. 15.0 15.1 Berns, N et al. (2014) A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche. J. Cell. Sci. 127 2736-48 PubMed GONUTS page
  16. Deng, W & Lin, H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int. Rev. Cytol. 203 93-138 PubMed GONUTS page
  17. 17.0 17.1 Sarpal, R et al. (2012) Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function. J. Cell. Sci. 125 233-45 PubMed GONUTS page
  18. Desai, R et al. (2013) Monomeric α-catenin links cadherin to the actin cytoskeleton. Nat. Cell Biol. 15 261-73 PubMed GONUTS page