DROME:CSKP

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	CASK (synonyms: Caki, cmg)
Protein Name(s)	Peripheral plasma membrane protein CASK dCASK Calcium/calmodulin-dependent protein kinase CAKI Camguk
External Links
UniProt	Q24210
EMBL	U53190 X94264 AE014297 AE014297 AE014297 AY094916 BT003532 BT003550 BT046172
PIR	S69210
RefSeq	NP_001097862.1 NP_524441.2 NP_732661.1 NP_732662.2
UniGene	Dm.7404
ProteinModelPortal	Q24210
SMR	Q24210
BioGrid	67530
DIP	DIP-19769N
IntAct	Q24210
STRING	7227.FBpp0083559
TCDB	9.B.106.3.2
PaxDb	Q24210
EnsemblMetazoa	FBtr0084161
GeneID	42567
KEGG	dme:Dmel_CG6703
CTD	8573
FlyBase	FBgn0013759
eggNOG	COG0515
GeneTree	ENSGT00760000118866
InParanoid	Q24210
KO	K06103
OMA	HEYLEYG
OrthoDB	EOG79CXZ5
PhylomeDB	Q24210
BRENDA	2.7.11.17
Reactome	REACT_184300 REACT_256915
SignaLink	Q24210
GenomeRNAi	42567
NextBio	829455
PRO	PR:Q24210
Proteomes	UP000000803
Bgee	Q24210
ExpressionAtlas	Q24210
GO	GO:0005954 GO:0031594 GO:0005886 GO:0061174 GO:0005524 GO:0004683 GO:0042043 GO:0004674 GO:0008344 GO:0007628 GO:0007615 GO:0007298 GO:0007155 GO:0007163 GO:0046331 GO:0040011 GO:0007616 GO:0008049 GO:0072375 GO:0007274 GO:0007269 GO:1900244 GO:0006468 GO:0008360 GO:0040012 GO:1900073 GO:0046928 GO:0008582 GO:2000331 GO:0016081 GO:0048488 GO:0016080
Gene3D	2.30.42.10 3.40.50.300
InterPro	IPR008145 IPR008144 IPR020590 IPR011009 IPR004172 IPR014775 IPR027417 IPR001478 IPR000719 IPR002290 IPR011511 IPR001452
Pfam	PF00625 PF02828 PF00595 PF00069 PF07653
SMART	SM00072 SM00569 SM00228 SM00220 SM00326
SUPFAM	SSF50044 SSF50156 SSF52540 SSF56112
PROSITE	PS00856 PS50052 PS51022 PS50106 PS50011 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0031594	neuromuscular junction	PMID:19379781^[1]	ECO:0000314			C	Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction.	complete CACAO 3172
	GO:0061174	type I terminal button	PMID:19379781^[1]	ECO:0000314			C	Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction.	complete CACAO 3173
	GO:0040011	locomotion	PMID:19379781^[1]	ECO:0000315			P	Figure 5C caki deficient larvae showed severe defect in locomotion compared to wild type.	complete CACAO 3174
	GO:2000331	regulation of terminal button organization	PMID:19379781^[1]	ECO:0000315			P	Figure 5Ab and B showed 20% increase in bouton number at neuromuscular junction in mutant caki fly compared to wild type. Possible new GO term is negative regulation of terminal button organization	complete CACAO 3175
	GO:0048488	synaptic vesicle endocytosis	PMID:19379781^[1]	ECO:0000315			P	Synaptic vesicle recycling was measured using FM1-43 dye. Figure 6Ab and B showed reduction in dye uptake in mutant caki fly	complete CACAO 3176
	GO:0007274	neuromuscular synaptic transmission	PMID:19379781^[1]	ECO:0000315			P	Intracellular recoding at neuromuscular junction Figure 7 BC, shows decrease in amplitude excitatory potential of caki mutant flies.	complete CACAO 3177
involved_in	GO:0007274	neuromuscular synaptic transmission	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0061174	type I terminal bouton	PMID:19379781^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:19379781^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0061174	type I terminal bouton	PMID:19379781^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:19379781^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9VCZ9	F	Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:19379781^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007274	neuromuscular synaptic transmission	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008582	regulation of synaptic growth at neuromuscular junction	PMID:24062638^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:23543616^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007615	anesthesia-resistant memory	PMID:23543616^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072375	medium-term memory	PMID:23543616^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:23173089^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	PMID:23145041^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900073	regulation of neuromuscular synaptic transmission	PMID:19379781^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0038975	P	Seeded From UniProt	complete
involved_in	GO:0040012	regulation of locomotion	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900073	regulation of neuromuscular synaptic transmission	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:19379781^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0040012	regulation of locomotion	PMID:19379781^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0038975	P	Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	PMID:19379781^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0038975	P	Seeded From UniProt	complete
involved_in	GO:0008049	male courtship behavior	PMID:21059886^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	PMID:21059886^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	PMID:15872064^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:12766944^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016081	synaptic vesicle docking	PMID:10798391^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	PMID:10798391^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	PMID:10798391^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	PMID:8617233^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P	Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 Sun, M et al. (2009) Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci. Res. 64 362-71 PubMed GONUTS page
↑ Gillespie, JM & Hodge, JJ (2013) CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning. Front Mol Neurosci 6 27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Malik, BR et al. (2013) CASK and CaMKII function in the mushroom body α'/β' neurons during Drosophila memory formation. Front Neural Circuits 7 52 PubMed GONUTS page
↑ Aranjuez, G et al. (2012) On the role of PDZ domain-encoding genes in Drosophila border cell migration. G3 (Bethesda) 2 1379-91 PubMed GONUTS page
↑ Maiya, R et al. (2012) DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance. PLoS ONE 7 e48967 PubMed GONUTS page
↑ ^6.0 ^6.1 Slawson, JB et al. (2011) Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains. Genetics 187 171-84 PubMed GONUTS page
↑ Zordan, MA et al. (2005) Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release. J. Neurophysiol. 94 1074-83 PubMed GONUTS page
↑ Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page
↑ Martin, JR & Ollo, R (1996) A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed. EMBO J. 15 1865-76 PubMed GONUTS page

[PMID:19379781-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 Sun, M et al. (2009) Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci. Res. 64 362-71 PubMed GONUTS page

[PMID:24062638-2] Gillespie, JM & Hodge, JJ (2013) CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning. Front Mol Neurosci 6 27 PubMed GONUTS page

[PMID:23543616-3] 3.0 ^3.1 ^3.2 Malik, BR et al. (2013) CASK and CaMKII function in the mushroom body α'/β' neurons during Drosophila memory formation. Front Neural Circuits 7 52 PubMed GONUTS page

[PMID:23173089-4] Aranjuez, G et al. (2012) On the role of PDZ domain-encoding genes in Drosophila border cell migration. G3 (Bethesda) 2 1379-91 PubMed GONUTS page

[PMID:23145041-5] Maiya, R et al. (2012) DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance. PLoS ONE 7 e48967 PubMed GONUTS page

[PMID:21059886-6] 6.0 ^6.1 Slawson, JB et al. (2011) Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains. Genetics 187 171-84 PubMed GONUTS page

[PMID:15872064-7] Zordan, MA et al. (2005) Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release. J. Neurophysiol. 94 1074-83 PubMed GONUTS page

[PMID:12766944-8] Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page

[PMID:10798391-9] 9.0 ^9.1 ^9.2 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page

[PMID:8617233-10] Martin, JR & Ollo, R (1996) A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed. EMBO J. 15 1865-76 PubMed GONUTS page

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DROME:CSKP

Contents

Annotations

Notes

References

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