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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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DROME:CSKP

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) CASK (synonyms: Caki, cmg)
Protein Name(s) Peripheral plasma membrane protein CASK

dCASK Calcium/calmodulin-dependent protein kinase CAKI Camguk

External Links
UniProt Q24210
EMBL U53190
X94264
AE014297
AE014297
AE014297
AY094916
BT003532
BT003550
BT046172
PIR S69210
RefSeq NP_001097862.1
NP_524441.2
NP_732661.1
NP_732662.2
UniGene Dm.7404
ProteinModelPortal Q24210
SMR Q24210
BioGrid 67530
DIP DIP-19769N
IntAct Q24210
STRING 7227.FBpp0083559
TCDB 9.B.106.3.2
PaxDb Q24210
EnsemblMetazoa FBtr0084161
GeneID 42567
KEGG dme:Dmel_CG6703
CTD 8573
FlyBase FBgn0013759
eggNOG COG0515
GeneTree ENSGT00760000118866
InParanoid Q24210
KO K06103
OMA HEYLEYG
OrthoDB EOG79CXZ5
PhylomeDB Q24210
BRENDA 2.7.11.17
Reactome REACT_184300
REACT_256915
SignaLink Q24210
GenomeRNAi 42567
NextBio 829455
PRO PR:Q24210
Proteomes UP000000803
Bgee Q24210
ExpressionAtlas Q24210
GO GO:0005954
GO:0031594
GO:0005886
GO:0061174
GO:0005524
GO:0004683
GO:0042043
GO:0004674
GO:0008344
GO:0007628
GO:0007615
GO:0007298
GO:0007155
GO:0007163
GO:0046331
GO:0040011
GO:0007616
GO:0008049
GO:0072375
GO:0007274
GO:0007269
GO:1900244
GO:0006468
GO:0008360
GO:0040012
GO:1900073
GO:0046928
GO:0008582
GO:2000331
GO:0016081
GO:0048488
GO:0016080
Gene3D 2.30.42.10
3.40.50.300
InterPro IPR008145
IPR008144
IPR020590
IPR011009
IPR004172
IPR014775
IPR027417
IPR001478
IPR000719
IPR002290
IPR011511
IPR001452
Pfam PF00625
PF02828
PF00595
PF00069
PF07653
SMART SM00072
SM00569
SM00228
SM00220
SM00326
SUPFAM SSF50044
SSF50156
SSF52540
SSF56112
PROSITE PS00856
PS50052
PS51022
PS50106
PS50011
PS50002

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031594

neuromuscular junction

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction.

complete
CACAO 3172

GO:0061174

type I terminal button

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Figure Ba, CAKI co-localized with DNRX (figure Ba’) at boutons at neuromuscular junction.

complete
CACAO 3173

GO:0040011

locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5C caki deficient larvae showed severe defect in locomotion compared to wild type.

complete
CACAO 3174

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Figure 5Ab and B showed 20% increase in bouton number at neuromuscular junction in mutant caki fly compared to wild type. Possible new GO term is negative regulation of terminal button organization

complete
CACAO 3175

GO:0048488

synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Synaptic vesicle recycling was measured using FM1-43 dye. Figure 6Ab and B showed reduction in dye uptake in mutant caki fly

complete
CACAO 3176

GO:0007274

neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Intracellular recoding at neuromuscular junction Figure 7 BC, shows decrease in amplitude excitatory potential of caki mutant flies.

complete
CACAO 3177

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004683

calmodulin-dependent protein kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.17

F

Seeded From UniProt

complete

GO:0004683

calmodulin-dependent protein kinase activity

PMID:8617233[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004683

calmodulin-dependent protein kinase activity

PMID:8617233[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005515

protein binding

PMID:14687552[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q00168

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15901771[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q02280

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19379781[1]

IPI: Inferred from Physical Interaction

FB:FBgn0038975

F

Seeded From UniProt

complete

GO:0005516

calmodulin binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005954

calcium- and calmodulin-dependent protein kinase complex

PMID:8617233[3]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:14527345[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007163

establishment or maintenance of cell polarity

PMID:12766944[7]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007269

neurotransmitter secretion

PMID:10798391[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:23173089[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007615

anesthesia-resistant memory

PMID:23543616[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007616

long-term memory

PMID:23543616[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007628

adult walking behavior

PMID:8617233[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008049

male courtship behavior

PMID:21059886[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008344

adult locomotory behavior

PMID:21059886[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:14527345[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008582

regulation of synaptic growth at neuromuscular junction

PMID:24062638[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016080

synaptic vesicle targeting

PMID:10798391[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016081

synaptic vesicle docking

PMID:10798391[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040011

locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040012

regulation of locomotion

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0038975

P

Seeded From UniProt

complete

GO:0040012

regulation of locomotion

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042043

neurexin family protein binding

PMID:19379781[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VCZ9

F

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:19363474[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046928

regulation of neurotransmitter secretion

PMID:15872064[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048488

synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048488

synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0061174

type I terminal bouton

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0061174

type I terminal bouton

PMID:19379781[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0072375

medium-term memory

PMID:23543616[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900073

regulation of neuromuscular synaptic transmission

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0038975

P

Seeded From UniProt

complete

GO:1900073

regulation of neuromuscular synaptic transmission

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900244

positive regulation of synaptic vesicle endocytosis

PMID:19379781[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0038975

P

Seeded From UniProt

complete

GO:1900244

positive regulation of synaptic vesicle endocytosis

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000331

regulation of terminal button organization

PMID:19379781[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 1.22 1.23 1.24 1.25 1.26 Sun, M et al. (2009) Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci. Res. 64 362-71 PubMed GONUTS page
  2. 2.0 2.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Martin, JR & Ollo, R (1996) A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed. EMBO J. 15 1865-76 PubMed GONUTS page
  4. Lu, CS et al. (2003) Regulation of the Ca2+/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Neuron 40 1185-97 PubMed GONUTS page
  5. Marble, DD et al. (2005) Camguk/CASK enhances Ether-á-go-go potassium current by a phosphorylation-dependent mechanism. J. Neurosci. 25 4898-907 PubMed GONUTS page
  6. 6.0 6.1 Kiger, AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2 27 PubMed GONUTS page
  7. Humbert, P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25 542-53 PubMed GONUTS page
  8. 8.0 8.1 8.2 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page
  9. Aranjuez, G et al. (2012) On the role of PDZ domain-encoding genes in Drosophila border cell migration. G3 (Bethesda) 2 1379-91 PubMed GONUTS page
  10. 10.0 10.1 10.2 Malik, BR et al. (2013) CASK and CaMKII function in the mushroom body α'/β' neurons during Drosophila memory formation. Front Neural Circuits 7 52 PubMed GONUTS page
  11. 11.0 11.1 Slawson, JB et al. (2011) Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains. Genetics 187 171-84 PubMed GONUTS page
  12. Gillespie, JM & Hodge, JJ (2013) CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning. Front Mol Neurosci 6 27 PubMed GONUTS page
  13. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page
  14. Zordan, MA et al. (2005) Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release. J. Neurophysiol. 94 1074-83 PubMed GONUTS page