DROME:CP314

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	shd (synonyms: CYP314A1)
Protein Name(s)	Ecdysone 20-monooxygenase E20MO CYPCCCXIVA1 Cytochrome P450 314a1, mitochondrial Protein shade
External Links
UniProt	Q9VUF8
EMBL	AF484414 AE014296 AY089309
RefSeq	NP_001261843.1 NP_648709.2 NP_996074.1
UniGene	Dm.5109
ProteinModelPortal	Q9VUF8
SMR	Q9VUF8
BioGrid	64922
IntAct	Q9VUF8
PaxDb	Q9VUF8
PRIDE	Q9VUF8
EnsemblMetazoa	FBtr0075676 FBtr0333031
GeneID	39592
KEGG	dme:Dmel_CG13478
UCSC	CG13478-RA
CTD	56961
FlyBase	FBgn0003388
eggNOG	COG2124
GeneTree	ENSGT00760000119243
InParanoid	Q9VUF8
KO	K10723
OMA	QRDSYYG
OrthoDB	EOG7Z95N9
PhylomeDB	Q9VUF8
BioCyc	MetaCyc:MONOMER-7726
BRENDA	1.14.99.22
Reactome	REACT_233777 REACT_246917 REACT_252525 REACT_252826 REACT_256597 REACT_263220
UniPathway	UPA00765
GenomeRNAi	39592
NextBio	814420
Proteomes	UP000000803
Bgee	Q9VUF8
ExpressionAtlas	Q9VUF8
GO	GO:0031966 GO:0005739 GO:0004501 GO:0020037 GO:0005506 GO:0007298 GO:0007417 GO:0007391 GO:0045456 GO:0007295 GO:0008258 GO:0007494
Gene3D	1.10.630.10
InterPro	IPR001128 IPR017972 IPR002401
Pfam	PF00067
PRINTS	PR00463 PR00385
SUPFAM	SSF48264
PROSITE	PS00086

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0035074	pupation	PMID:27226323^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007298	border follicle cell migration	PMID:24373956^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007494	midgut development	PMID:14610274^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045456	ecdysteroid biosynthetic process	PMID:14610274^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045456	ecdysteroid biosynthetic process	PMID:14610274^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:14610274^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007295	growth of a germarium-derived egg chamber	PMID:14610274^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004501	ecdysone 20-monooxygenase activity	PMID:14610274^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14610274^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007391	dorsal closure	PMID:12676319^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:12676319^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008258	head involution	PMID:12676319^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR036396	F	Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR017972 InterPro:IPR036396	F	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR036396	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001128 InterPro:IPR002401 InterPro:IPR017972 InterPro:IPR036396	P	Seeded From UniProt	complete
enables	GO:0004501	ecdysone 20-monooxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.99.22	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C	Seeded From UniProt	complete
involved_in	GO:0045456	ecdysteroid biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00765	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Akagi, K et al. (2016) A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. Development 143 2410-6 PubMed GONUTS page
↑ Domanitskaya, E et al. (2014) Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev. Biol. 386 408-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Petryk, A et al. (2003) Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc. Natl. Acad. Sci. U.S.A. 100 13773-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Giesen, K et al. (2003) Regulation of glial cell number and differentiation by ecdysone and Fos signaling. Mech. Dev. 120 401-13 PubMed GONUTS page

[PMID:27226323-1] Akagi, K et al. (2016) A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. Development 143 2410-6 PubMed GONUTS page

[PMID:24373956-2] Domanitskaya, E et al. (2014) Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev. Biol. 386 408-18 PubMed GONUTS page

[PMID:14610274-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Petryk, A et al. (2003) Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc. Natl. Acad. Sci. U.S.A. 100 13773-8 PubMed GONUTS page

[PMID:12676319-4] 4.0 ^4.1 ^4.2 Giesen, K et al. (2003) Regulation of glial cell number and differentiation by ecdysone and Fos signaling. Mech. Dev. 120 401-13 PubMed GONUTS page

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DROME:CP314

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