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DROME:CP314

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) shd (synonyms: CYP314A1)
Protein Name(s) Ecdysone 20-monooxygenase

E20MO CYPCCCXIVA1 Cytochrome P450 314a1, mitochondrial Protein shade

External Links
UniProt Q9VUF8
EMBL AF484414
AE014296
AY089309
RefSeq NP_001261843.1
NP_648709.2
NP_996074.1
UniGene Dm.5109
ProteinModelPortal Q9VUF8
SMR Q9VUF8
BioGrid 64922
IntAct Q9VUF8
PaxDb Q9VUF8
PRIDE Q9VUF8
EnsemblMetazoa FBtr0075676
FBtr0333031
GeneID 39592
KEGG dme:Dmel_CG13478
UCSC CG13478-RA
CTD 56961
FlyBase FBgn0003388
eggNOG COG2124
GeneTree ENSGT00760000119243
InParanoid Q9VUF8
KO K10723
OMA QRDSYYG
OrthoDB EOG7Z95N9
PhylomeDB Q9VUF8
BioCyc MetaCyc:MONOMER-7726
BRENDA 1.14.99.22
Reactome REACT_233777
REACT_246917
REACT_252525
REACT_252826
REACT_256597
REACT_263220
UniPathway UPA00765
GenomeRNAi 39592
NextBio 814420
Proteomes UP000000803
Bgee Q9VUF8
ExpressionAtlas Q9VUF8
GO GO:0031966
GO:0005739
GO:0004501
GO:0020037
GO:0005506
GO:0007298
GO:0007417
GO:0007391
GO:0045456
GO:0007295
GO:0008258
GO:0007494
Gene3D 1.10.630.10
InterPro IPR001128
IPR017972
IPR002401
Pfam PF00067
PRINTS PR00463
PR00385
SUPFAM SSF48264
PROSITE PS00086

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004497

monooxygenase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0503

F

Seeded From UniProt

complete

GO:0004501

ecdysone 20-monooxygenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.14.99.22

F

Seeded From UniProt

complete

GO:0004501

ecdysone 20-monooxygenase activity

PMID:14610274[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005506

iron ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128
InterPro:IPR002401

F

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:14610274[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007295

growth of a germarium-derived egg chamber

PMID:14610274[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007298

border follicle cell migration

PMID:24373956[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12676319[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:14610274[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007417

central nervous system development

PMID:12676319[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007494

midgut development

PMID:14610274[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008258

head involution

PMID:12676319[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016491

oxidoreductase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972

F

Seeded From UniProt

complete

GO:0020037

heme binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128
InterPro:IPR002401

F

Seeded From UniProt

complete

GO:0031966

mitochondrial membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0171

C

Seeded From UniProt

complete

GO:0045456

ecdysteroid biosynthetic process

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00765

P

Seeded From UniProt

complete

GO:0045456

ecdysteroid biosynthetic process

PMID:14610274[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045456

ecdysteroid biosynthetic process

PMID:14610274[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128
InterPro:IPR002401
InterPro:IPR017972

P

Seeded From UniProt

complete

GO:0055114

oxidation-reduction process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Petryk, A et al. (2003) Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone. Proc. Natl. Acad. Sci. U.S.A. 100 13773-8 PubMed GONUTS page
  2. Domanitskaya, E et al. (2014) Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev. Biol. 386 408-18 PubMed GONUTS page
  3. 3.0 3.1 3.2 Giesen, K et al. (2003) Regulation of glial cell number and differentiation by ecdysone and Fos signaling. Mech. Dev. 120 401-13 PubMed GONUTS page