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DROME:CATL

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Cp1 (synonyms: fs(2)50Ca)
Protein Name(s) Cathepsin L

Cysteine proteinase 1 Cathepsin L heavy chain Cathepsin L light chain

External Links
UniProt Q95029
EMBL U75652
AF012089
AE013599
AE013599
BT016071
D31970
RefSeq NP_523735.2
NP_725347.1
UniGene Dm.7400
ProteinModelPortal Q95029
SMR Q95029
BioGrid 62300
IntAct Q95029
MINT MINT-814156
STRING 7227.FBpp0086719
MEROPS C01.092
PaxDb Q95029
PRIDE Q95029
EnsemblMetazoa FBtr0087593
GeneID 36546
KEGG dme:Dmel_CG6692
CTD 36546
FlyBase FBgn0013770
eggNOG COG4870
GeneTree ENSGT00760000118871
InParanoid Q95029
KO K01365
OMA ACTSLAR
OrthoDB EOG786H3P
PhylomeDB Q95029
Reactome REACT_180993
REACT_184283
REACT_215998
REACT_235465
REACT_247955
REACT_257704
REACT_268980
GenomeRNAi 36546
NextBio 799136
PRO PR:Q95029
Proteomes UP000000803
Bgee Q95029
ExpressionAtlas Q95029
GO GO:0045169
GO:0005764
GO:0004197
GO:0048102
GO:0007586
GO:0006508
GO:0035071
InterPro IPR025661
IPR000169
IPR025660
IPR013128
IPR000668
IPR013201
PANTHER PTHR12411
Pfam PF08246
PF00112
PRINTS PR00705
SMART SM00848
SM00645
PROSITE PS00640
PS00139
PS00639

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004197

cysteine-type endopeptidase activity

PMID:22150223[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000274640

C

Seeded From UniProt

complete

GO:0005764

lysosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0458

C

Seeded From UniProt

complete

GO:0005764

lysosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

GO:0005764

lysosome

PMID:25173815[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000668

P

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0006508

proteolysis

PMID:22150223[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006508

proteolysis

PMID:25173815[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006508

proteolysis

PMID:25173815[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007586

digestion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0222

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008233

peptidase activity

PMID:25173815[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008234

cysteine-type peptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000668
InterPro:IPR013128

F

Seeded From UniProt

complete

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0035071

salivary gland cell autophagic cell death

PMID:12593804[3]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0045169

fusome

PMID:18355804[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0048102

autophagic cell death

PMID:12593804[3]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0051603

proteolysis involved in cellular protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000274640

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Tseng, TS et al. (2012) A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin. Biochem. J. 442 563-72 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Kowalewski-Nimmerfall, E et al. (2014) Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development. Biochim. Biophys. Acta 1843 2900-12 PubMed GONUTS page
  3. 3.0 3.1 Gorski, SM et al. (2003) A SAGE approach to discovery of genes involved in autophagic cell death. Curr. Biol. 13 358-63 PubMed GONUTS page
  4. Lighthouse, DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev. Biol. 317 59-71 PubMed GONUTS page