DICDI:TGRC1

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	tgrC1 (synonyms: gp150, lagC, lagC1)
Protein Name(s)	Tiger protein C1 Loose aggregate C protein Loose aggregate C1 protein Transmembrane, IPT, Ig, E-set, Repeat protein C1
External Links
UniProt	P42523
EMBL	U09478 AF258615 AAFI02000037
PIR	A54280
RefSeq	XP_641123.1
STRING	44689.DDB_0214927
PRIDE	P42523
EnsemblProtists	DDB0214927
GeneID	8622682
KEGG	ddi:DDB_G0280531
dictyBase	DDB_G0280531
InParanoid	P42523
PhylomeDB	P42523
Proteomes	UP000002195 UP000002195
GO	GO:0030054 GO:0005887 GO:0031152 GO:0009988 GO:0097656 GO:1902168 GO:0035176
Gene3D	2.60.40.10
InterPro	IPR013783 IPR014756 IPR002909
Pfam	PF01833
SUPFAM	SSF81296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0099138	altruistic, chimeric sorocarp development	PMID:28120827^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	PMID:29038229^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(DDB:DDB_G0280689) happens_during:(GO:0099120)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:29038229^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(DDB:DDB_G0280689)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:11071787^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	PMID:11071787^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08796	P		Seeded From UniProt	complete
part_of	GO:0044291	cell-cell contact zone	PMID:11071787^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031149	sorocarp stalk cell differentiation	PMID:25894230^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q55GQ4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099120	socially cooperative development	PMID:23910661^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:25887420^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098635	protein complex involved in cell-cell adhesion	PMID:24490801^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	has_participant:(UniProtKB:Q54V07)	Seeded From UniProt	complete
involved_in	GO:0090073	positive regulation of protein homodimerization activity	PMID:24490801^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q54V07)	Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:1577768^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:24490801^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:24490801^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q54V07) happens_during:(GO:0030587)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:24490801^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0030587)	Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:23477311^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(UniProtKB:Q54V07)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097656	cell-cell self recognition	PMID:21700835^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q54V07	P		Seeded From UniProt	complete
involved_in	GO:1902168	response to catechin	PMID:23516620^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:7926779^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031152	aggregation involved in sorocarp development	PMID:14651934^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009988	cell-cell recognition	PMID:19285397^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15261655^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gruenheit, N et al. (2017) A polychromatic 'greenbeard' locus determines patterns of cooperation in a social amoeba. Nat Commun 8 14171 PubMed GONUTS page
↑ ^2.0 ^2.1 Hirose, S et al. (2017) The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in allorecognition. J. Cell. Sci. 130 4002-4012 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wang, J et al. (2000) The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development. Dev. Biol. 227 734-45 PubMed GONUTS page
↑ Wang, Y & Shaulsky, G (2015) TgrC1 Has Distinct Functions in Dictyostelium Development and Allorecognition. PLoS ONE 10 e0124270 PubMed GONUTS page
↑ Ho, HI et al. (2013) Kin recognition protects cooperators against cheaters. Curr. Biol. 23 1590-5 PubMed GONUTS page
↑ Rosengarten, RD et al. (2015) Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum. BMC Genomics 16 294 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Chen, G et al. (2014) Assembly of the TgrB1-TgrC1 cell adhesion complex during Dictyostelium discoideum development. Biochem. J. 459 241-9 PubMed GONUTS page
↑ Gao, EN et al. (1992) Purification and partial characterization of a cell adhesion molecule (gp150) involved in postaggregation stage cell-cell binding in Dictyostelium discoideum. J. Biol. Chem. 267 9409-15 PubMed GONUTS page
↑ Chen, G et al. (2013) TgrC1 mediates cell-cell adhesion by interacting with TgrB1 via mutual IPT/TIG domains during development of Dictyostelium discoideum. Biochem. J. 452 259-69 PubMed GONUTS page
↑ Hirose, S et al. (2011) Self-recognition in social amoebae is mediated by allelic pairs of tiger genes. Science 333 467-70 PubMed GONUTS page
↑ McQuade, KJ et al. (2013) The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum. PLoS ONE 8 e59275 PubMed GONUTS page
↑ Dynes, JL et al. (1994) LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes Dev. 8 948-58 PubMed GONUTS page
↑ Kibler, K et al. (2003) A cell-adhesion pathway regulates intercellular communication during Dictyostelium development. Dev. Biol. 264 506-21 PubMed GONUTS page
↑ Benabentos, R et al. (2009) Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium. Curr. Biol. 19 567-72 PubMed GONUTS page
↑ Weijer, CJ (2004) Dictyostelium morphogenesis. Curr. Opin. Genet. Dev. 14 392-8 PubMed GONUTS page

[PMID:28120827-1] Gruenheit, N et al. (2017) A polychromatic 'greenbeard' locus determines patterns of cooperation in a social amoeba. Nat Commun 8 14171 PubMed GONUTS page

[PMID:29038229-2] 2.0 ^2.1 Hirose, S et al. (2017) The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in allorecognition. J. Cell. Sci. 130 4002-4012 PubMed GONUTS page

[PMID:11071787-3] 3.0 ^3.1 ^3.2 Wang, J et al. (2000) The membrane glycoprotein gp150 is encoded by the lagC gene and mediates cell-cell adhesion by heterophilic binding during Dictyostelium development. Dev. Biol. 227 734-45 PubMed GONUTS page

[PMID:25894230-4] Wang, Y & Shaulsky, G (2015) TgrC1 Has Distinct Functions in Dictyostelium Development and Allorecognition. PLoS ONE 10 e0124270 PubMed GONUTS page

[PMID:23910661-5] Ho, HI et al. (2013) Kin recognition protects cooperators against cheaters. Curr. Biol. 23 1590-5 PubMed GONUTS page

[PMID:25887420-6] Rosengarten, RD et al. (2015) Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum. BMC Genomics 16 294 PubMed GONUTS page

[PMID:24490801-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Chen, G et al. (2014) Assembly of the TgrB1-TgrC1 cell adhesion complex during Dictyostelium discoideum development. Biochem. J. 459 241-9 PubMed GONUTS page

[PMID:1577768-8] Gao, EN et al. (1992) Purification and partial characterization of a cell adhesion molecule (gp150) involved in postaggregation stage cell-cell binding in Dictyostelium discoideum. J. Biol. Chem. 267 9409-15 PubMed GONUTS page

[PMID:23477311-9] Chen, G et al. (2013) TgrC1 mediates cell-cell adhesion by interacting with TgrB1 via mutual IPT/TIG domains during development of Dictyostelium discoideum. Biochem. J. 452 259-69 PubMed GONUTS page

[PMID:21700835-10] Hirose, S et al. (2011) Self-recognition in social amoebae is mediated by allelic pairs of tiger genes. Science 333 467-70 PubMed GONUTS page

[PMID:23516620-11] McQuade, KJ et al. (2013) The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum. PLoS ONE 8 e59275 PubMed GONUTS page

[PMID:7926779-12] Dynes, JL et al. (1994) LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium. Genes Dev. 8 948-58 PubMed GONUTS page

[PMID:14651934-13] Kibler, K et al. (2003) A cell-adhesion pathway regulates intercellular communication during Dictyostelium development. Dev. Biol. 264 506-21 PubMed GONUTS page

[PMID:19285397-14] Benabentos, R et al. (2009) Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium. Curr. Biol. 19 567-72 PubMed GONUTS page

[PMID:15261655-15] Weijer, CJ (2004) Dictyostelium morphogenesis. Curr. Opin. Genet. Dev. 14 392-8 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

DICDI:TGRC1

Contents

Annotations

Notes

References

a

c

d

e

h

i

m

o

p

r

s

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools