DANRE:TILB

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	lrrc6 (synonyms: lrrc6l)
Protein Name(s)	Protein tilB homolog Leucine-rich repeat-containing 6-like protein Leucine-rich repeat-containing protein 6 Seahorse
External Links
UniProt	B3DH20
EMBL	AY618925 BC162607
RefSeq	NP_001002311.1
UniGene	Dr.80306
STRING	7955.ENSDARP00000069830
GeneID	432388
KEGG	dre:432388
CTD	23639
ZFIN	ZDB-GENE-040827-2
eggNOG	NOG294986
HOGENOM	HOG000258801
HOVERGEN	HBG053229
InParanoid	B3DH20
NextBio	20831025
PRO	PR:B3DH20
Proteomes	UP000000437
GO	GO:0005929 GO:0005737
InterPro	IPR001611 IPR003603
SMART	SM00446
PROSITE	PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0044085	cellular component biogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0007010	cytoskeleton organization	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0000226	microtubule cytoskeleton organization	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0043933	macromolecular complex subunit organization	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0071822	protein complex subunit organization	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0070271	protein complex biogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0006461	protein complex assembly	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0022607	cellular component assembly	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0032989	cellular component morphogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0048858	cell projection morphogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0060271	cilium morphogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0010927	cellular component assembly involved in morphogenesis	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0030031	cell projection assembly	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
	GO:0042384	cilium assembly	PMID:0000037^[1]	ECO:0000314			P	Ruth	complete
involved_in	GO:0060294	cilium movement involved in cell motility	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090616-1	P	Seeded From UniProt	complete
involved_in	GO:0060294	cilium movement involved in cell motility	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:17576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3 ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7 ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-090515-2	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090616-1	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18539122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:18539122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080929-8	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:17576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0044458	motile cilium assembly	PMID:23858445^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-4 ZFIN:ZDB-MRPHLNO-130923-1	P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:18539122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-139	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-090616-1	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:19395640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18539122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18539122^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-080930-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18539122^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:23858445^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-130926-3	P	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:17576052^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-070808-19	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:9334285^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-139	P	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-139	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980410-139	P	Seeded From UniProt	complete
involved_in	GO:0060294	cilium movement involved in cell motility	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002705561 ZFIN:ZDB-GENE-040827-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1915134 PANTHER:PTN002705561 ZFIN:ZDB-GENE-040827-2	P	Seeded From UniProt	complete
involved_in	GO:0044458	motile cilium assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002705561 UniProtKB:Q86X45 ZFIN:ZDB-GENE-040827-2	P	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014395 PANTHER:PTN002705561	C	Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002705561 UniProtKB:O43822	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002705561 UniProtKB:Q86X45	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014395 MGI:MGI:1859553 PANTHER:PTN002705561 UniProtKB:O43822 UniProtKB:Q86X45	C	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000833862 ZFIN:ZDB-GENE-040827-2	P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Hattori, M et al. (1975) Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid). Biochemistry 14 5033-45 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Serluca, FC et al. (2009) Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development 136 1621-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Zhao, C & Malicki, J (2007) Genetic defects of pronephric cilia in zebrafish. Mech. Dev. 124 605-16 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page
↑ Chen, JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 293-302 PubMed GONUTS page
↑ ^6.0 ^6.1 Zhao, L et al. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proc. Natl. Acad. Sci. U.S.A. 110 12697-702 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:0000037-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Hattori, M et al. (1975) Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid). Biochemistry 14 5033-45 PubMed GONUTS page

[PMID:19395640-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Serluca, FC et al. (2009) Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development 136 1621-31 PubMed GONUTS page

[PMID:17576052-3] 3.0 ^3.1 ^3.2 ^3.3 Zhao, C & Malicki, J (2007) Genetic defects of pronephric cilia in zebrafish. Mech. Dev. 124 605-16 PubMed GONUTS page

[PMID:18539122-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page

[PMID:9007249-5] Chen, JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 293-302 PubMed GONUTS page

[PMID:23858445-6] 6.0 ^6.1 Zhao, L et al. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proc. Natl. Acad. Sci. U.S.A. 110 12697-702 PubMed GONUTS page

[PMID:9334285-7] 7.0 ^7.1 ^7.2 ^7.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:TILB

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