DANRE:Q9DG41

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	No Information Provided.
Protein Name(s)	Hyaluronan synthase 2 (ECO:0000313 with EMBL:AAG17180.1) Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000014628)
External Links
UniProt	Q9DG41
EMBL	BX936449 AF190742 BC100130
RefSeq	NP_705936.1
UniGene	Dr.82516
CAZy	GT2
Ensembl	ENSDART00000018931 ENSDART00000053754
GeneID	260350
KEGG	dre:260350
CTD	3037
ZFIN	ZDB-GENE-020828-1
GeneTree	ENSGT00390000010337
HOGENOM	HOG000112847
HOVERGEN	HBG000189
KO	K00752
OMA	TAYIMGY
OrthoDB	EOG77WWBZ
PhylomeDB	Q9DG41
TreeFam	TF332506
NextBio	20804721
PRO	PR:Q9DG41
Proteomes	UP000000437
GO	GO:0005887 GO:0016020 GO:0050501 GO:0003171 GO:0003181 GO:0021535 GO:0042074 GO:0060030 GO:0035050 GO:0003146 GO:0001947 GO:0030213 GO:0008078 GO:0035810 GO:2000223 GO:0070295 GO:0001756
Gene3D	3.90.550.10
InterPro	IPR026107 IPR028371 IPR029044
PANTHER	PTHR22913 PTHR22913:SF7
SUPFAM	SSF53448

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070295	renal water absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	F	Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P	Seeded From UniProt	complete
involved_in	GO:2000223	regulation of BMP signaling pathway involved in heart jogging	PMID:23499359^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5	P	Seeded From UniProt	complete
involved_in	GO:0060030	dorsal convergence	PMID:17331724^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070516-4	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:14729574^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	EMBL:U54804	F	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:14729574^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	EMBL:U52524	F	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:14729574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:24430697^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-040426-2843	P	Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:18267096^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5 ZFIN:ZDB-MRPHLNO-060930-6	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26828861^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-160413-12	P	Seeded From UniProt	complete
involved_in	GO:0031101	fin regeneration	PMID:26828861^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-160413-11	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:14729574^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	EMBL:U54804	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:14729574^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	EMBL:U52524	P	Seeded From UniProt	complete
involved_in	GO:0021535	cell migration in hindbrain	PMID:17392791^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:14729574^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008078	mesodermal cell migration	PMID:14729574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003181	atrioventricular valve morphogenesis	PMID:21778427^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5	P	Seeded From UniProt	complete
involved_in	GO:0003171	atrioventricular valve development	PMID:21937601^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5 ZFIN:ZDB-MRPHLNO-111018-2	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:18267096^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-980528-2059	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:24430697^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-040426-2843	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18267096^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050228-1 ZFIN:ZDB-MRPHLNO-060930-5 ZFIN:ZDB-MRPHLNO-060930-6 ZFIN:ZDB-MRPHLNO-070710-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18267096^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060930-5 ZFIN:ZDB-MRPHLNO-060930-6	P	Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:14729574^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	PMID:24586357^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-130424-1 ZFIN:ZDB-MRPHLNO-140924-3 ZFIN:ZDB-MRPHLNO-140924-4	P	Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	F	Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000530809 UniProtKB:Q92819	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	C	Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	P	Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Veerkamp, J et al. (2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Dev. Cell 24 660-7 PubMed GONUTS page
↑ von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Bakkers, J et al. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131 525-37 PubMed GONUTS page
↑ ^4.0 ^4.1 Tong, X et al. (2014) Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nat Commun 5 3153 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
↑ ^6.0 ^6.1 Govindan, J et al. (2016) Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS ONE 11 e0148202 PubMed GONUTS page
↑ Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page
↑ Lagendijk, AK et al. (2011) MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ. Res. 109 649-57 PubMed GONUTS page
↑ Patra, C et al. (2011) Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish. Development 138 4499-509 PubMed GONUTS page
↑ Rost, MS & Sumanas, S (2014) Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish. PLoS ONE 9 e88614 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23499359-1] Veerkamp, J et al. (2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Dev. Cell 24 660-7 PubMed GONUTS page

[PMID:17331724-2] von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page

[PMID:14729574-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Bakkers, J et al. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131 525-37 PubMed GONUTS page

[PMID:24430697-4] 4.0 ^4.1 Tong, X et al. (2014) Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nat Commun 5 3153 PubMed GONUTS page

[PMID:18267096-5] 5.0 ^5.1 ^5.2 ^5.3 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page

[PMID:26828861-6] 6.0 ^6.1 Govindan, J et al. (2016) Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. PLoS ONE 11 e0148202 PubMed GONUTS page

[PMID:17392791-7] Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page

[PMID:21778427-8] Lagendijk, AK et al. (2011) MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ. Res. 109 649-57 PubMed GONUTS page

[PMID:21937601-9] Patra, C et al. (2011) Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish. Development 138 4499-509 PubMed GONUTS page

[PMID:24586357-10] Rost, MS & Sumanas, S (2014) Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish. PLoS ONE 9 e88614 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:Q9DG41

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