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DANRE:Q9DG41

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) Hyaluronan synthase 2 (ECO:0000313 with EMBL:AAG17180.1)

Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000014628)

External Links
UniProt Q9DG41
EMBL BX936449
AF190742
BC100130
RefSeq NP_705936.1
UniGene Dr.82516
CAZy GT2
Ensembl ENSDART00000018931
ENSDART00000053754
GeneID 260350
KEGG dre:260350
CTD 3037
ZFIN ZDB-GENE-020828-1
GeneTree ENSGT00390000010337
HOGENOM HOG000112847
HOVERGEN HBG000189
KO K00752
OMA TAYIMGY
OrthoDB EOG77WWBZ
PhylomeDB Q9DG41
TreeFam TF332506
NextBio 20804721
PRO PR:Q9DG41
Proteomes UP000000437
GO GO:0005887
GO:0016020
GO:0050501
GO:0003171
GO:0003181
GO:0021535
GO:0042074
GO:0060030
GO:0035050
GO:0003146
GO:0001947
GO:0030213
GO:0008078
GO:0035810
GO:2000223
GO:0070295
GO:0001756
Gene3D 3.90.550.10
InterPro IPR026107
IPR028371
IPR029044
PANTHER PTHR22913
PTHR22913:SF7
SUPFAM SSF53448

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001568

blood vessel development

PMID:24586357[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-130424-1
ZFIN:ZDB-MRPHLNO-140924-3
ZFIN:ZDB-MRPHLNO-140924-4

P

Seeded From UniProt

complete

GO:0001756

somitogenesis

PMID:14729574[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:18267096[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-050228-1
ZFIN:ZDB-MRPHLNO-060930-5
ZFIN:ZDB-MRPHLNO-060930-6
ZFIN:ZDB-MRPHLNO-070710-1

P

Seeded From UniProt

complete

GO:0001947

heart looping

PMID:18267096[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060930-5
ZFIN:ZDB-MRPHLNO-060930-6

P

Seeded From UniProt

complete

GO:0003146

heart jogging

PMID:18267096[3]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENE-980528-2059

P

Seeded From UniProt

complete

GO:0003171

atrioventricular valve development

PMID:21937601[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-060930-5
ZFIN:ZDB-MRPHLNO-111018-2

P

Seeded From UniProt

complete

GO:0003181

atrioventricular valve morphogenesis

PMID:21778427[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060930-5

P

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028371

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

C

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

P

Seeded From UniProt

complete

GO:0008078

mesodermal cell migration

PMID:14729574[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

PMID:14729574[2]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0021535

cell migration in hindbrain

PMID:17392791[6]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060930-5

P

Seeded From UniProt

complete

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028371

P

Seeded From UniProt

complete

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O35776

P

Seeded From UniProt

complete

GO:0030213

hyaluronan biosynthetic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

P

Seeded From UniProt

complete

GO:0030213

hyaluronan biosynthetic process

PMID:14729574[2]

ISS: Inferred from Sequence or Structural Similarity

EMBL:U52524

P

Seeded From UniProt

complete

GO:0030213

hyaluronan biosynthetic process

PMID:14729574[2]

ISS: Inferred from Sequence or Structural Similarity

EMBL:U54804

P

Seeded From UniProt

complete

GO:0035050

embryonic heart tube development

PMID:18267096[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060930-5
ZFIN:ZDB-MRPHLNO-060930-6

P

Seeded From UniProt

complete

GO:0035810

positive regulation of urine volume

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O35776

P

Seeded From UniProt

complete

GO:0042074

cell migration involved in gastrulation

PMID:14729574[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045226

extracellular polysaccharide biosynthetic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

P

Seeded From UniProt

complete

GO:0050501

hyaluronan synthase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028371

F

Seeded From UniProt

complete

GO:0050501

hyaluronan synthase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O35776

F

Seeded From UniProt

complete

GO:0050501

hyaluronan synthase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

F

Seeded From UniProt

complete

GO:0050501

hyaluronan synthase activity

PMID:14729574[2]

ISS: Inferred from Sequence or Structural Similarity

EMBL:U52524

F

Seeded From UniProt

complete

GO:0050501

hyaluronan synthase activity

PMID:14729574[2]

ISS: Inferred from Sequence or Structural Similarity

EMBL:U54804

F

Seeded From UniProt

complete

GO:0060030

dorsal convergence

PMID:17331724[7]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-070516-4

P

Seeded From UniProt

complete

GO:0070295

renal water absorption

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O35776

P

Seeded From UniProt

complete

GO:0085029

extracellular matrix assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000530809

P

Seeded From UniProt

complete

GO:2000223

regulation of BMP signaling pathway involved in heart jogging

PMID:23499359[8]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-060930-5

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Rost, MS & Sumanas, S (2014) Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish. PLoS ONE 9 e88614 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Bakkers, J et al. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development 131 525-37 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Smith, KA et al. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev. Cell 14 287-97 PubMed GONUTS page
  4. Patra, C et al. (2011) Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish. Development 138 4499-509 PubMed GONUTS page
  5. Lagendijk, AK et al. (2011) MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production. Circ. Res. 109 649-57 PubMed GONUTS page
  6. Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page
  7. von der Hardt, S et al. (2007) The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol. 17 475-87 PubMed GONUTS page
  8. Veerkamp, J et al. (2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Dev. Cell 24 660-7 PubMed GONUTS page