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DANRE:Q7ZW17
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | ptpn11a (ECO:0000313 with ZFIN:ZDB-GENE-030131-5911) | |
| Protein Name(s) | Tyrosine-protein phosphatase non-receptor type (ECO:0000256 with PIRNR:PIRNR000929) | |
| External Links | ||
| UniProt | Q7ZW17 | |
| EMBL | BC045328 BC164416 | |
| RefSeq | NP_956140.1 | |
| UniGene | Dr.104919 Dr.75924 | |
| SMR | Q7ZW17 | |
| STRING | 7955.ENSDARP00000076040 | |
| PRIDE | Q7ZW17 | |
| GeneID | 333979 | |
| KEGG | dre:333979 | |
| CTD | 333979 | |
| ZFIN | ZDB-GENE-030131-5911 | |
| HOGENOM | HOG000273907 | |
| HOVERGEN | HBG000223 | |
| KO | K07293 | |
| PhylomeDB | Q7ZW17 | |
| NextBio | 20810214 | |
| PRO | PR:Q7ZW17 | |
| Bgee | Q7ZW17 | |
| GO | GO:0005737 GO:0016791 GO:0004725 GO:0060028 GO:0060027 GO:0048703 GO:0007507 GO:0003146 GO:0060548 GO:0035335 | |
| Gene3D | 3.30.505.10 3.90.190.10 | |
| InterPro | IPR029021 IPR000980 IPR000387 IPR016130 IPR012152 IPR000242 | |
| Pfam | PF00017 PF00102 | |
| PIRSF | PIRSF000929 | |
| PRINTS | PR00700 PR00401 | |
| SMART | SM00194 SM00252 | |
| SUPFAM | SSF52799 SSF55550 | |
| PROSITE | PS50001 PS00383 PS50056 PS50055 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-101026-4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060028 |
convergent extension involved in axis elongation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-070904-9 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-041217-11 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-080801-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048703 |
embryonic viscerocranium morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENO-140805-4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048703 |
embryonic viscerocranium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-140805-2 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007507 |
heart development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-070904-9 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0003146 |
heart jogging |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-080801-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000414439 |
F |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Stewart, RA et al. (2010) Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev. Cell 18 750-62 PubMed GONUTS page
- ↑ Paardekooper Overman, J et al. (2014) PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice. Mol. Cell. Biol. 34 2874-89 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Jopling, C et al. (2007) Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 3 e225 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Bonetti, M et al. (2014) Distinct and overlapping functions of ptpn11 genes in Zebrafish development. PLoS ONE 9 e94884 PubMed GONUTS page
- ↑ Razzaque, MA et al. (2007) Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat. Genet. 39 1013-7 PubMed GONUTS page
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