It is now the 3rd CHALLENGE Period for CACAO Fall 2017! It will end on Sunday October 22, 2017 at 11:59 pm CDT
This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DANRE:Q7ZW17

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) ptpn11a (ECO:0000313 with ZFIN:ZDB-GENE-030131-5911)
Protein Name(s) Tyrosine-protein phosphatase non-receptor type (ECO:0000256 with PIRNR:PIRNR000929)
External Links
UniProt Q7ZW17
EMBL BC045328
BC164416
RefSeq NP_956140.1
UniGene Dr.104919
Dr.75924
SMR Q7ZW17
STRING 7955.ENSDARP00000076040
PRIDE Q7ZW17
GeneID 333979
KEGG dre:333979
CTD 333979
ZFIN ZDB-GENE-030131-5911
HOGENOM HOG000273907
HOVERGEN HBG000223
KO K07293
PhylomeDB Q7ZW17
NextBio 20810214
PRO PR:Q7ZW17
Bgee Q7ZW17
GO GO:0005737
GO:0016791
GO:0004725
GO:0060028
GO:0060027
GO:0048703
GO:0007507
GO:0003146
GO:0060548
GO:0035335
Gene3D 3.30.505.10
3.90.190.10
InterPro IPR029021
IPR000980
IPR000387
IPR016130
IPR012152
IPR000242
Pfam PF00017
PF00102
PIRSF PIRSF000929
PRINTS PR00700
PR00401
SMART SM00194
SM00252
SUPFAM SSF52799
SSF55550
PROSITE PS50001
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003146

heart jogging

PMID:18159945[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080801-1

P

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR012152
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

F

Seeded From UniProt

complete

GO:0004725

protein tyrosine phosphatase activity

PMID:18159945[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:24865967[2]

IPI: Inferred from Physical Interaction

ZFIN:ZDB-GENE-050417-455

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000040

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0006470

protein dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR012152

P

Seeded From UniProt

complete

GO:0007507

heart development

PMID:17603482[3]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070904-9

P

Seeded From UniProt

complete

GO:0016311

dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000387
InterPro:IPR016130

F

Seeded From UniProt

complete

GO:0016791

phosphatase activity

PMID:24736444[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000242
InterPro:IPR012152
InterPro:IPR016130

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.1.3.48

P

Seeded From UniProt

complete

GO:0035335

peptidyl-tyrosine dephosphorylation

PMID:18159945[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048703

embryonic viscerocranium morphogenesis

PMID:24736444[4]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-GENO-140805-4

P

Seeded From UniProt

complete

GO:0048703

embryonic viscerocranium morphogenesis

PMID:24736444[4]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-GENO-140805-2

P

Seeded From UniProt

complete

GO:0060027

convergent extension involved in gastrulation

PMID:18159945[1]

IGI: Inferred from Genetic Interaction

ZFIN:ZDB-MRPHLNO-041217-11
ZFIN:ZDB-MRPHLNO-080801-1

P

Seeded From UniProt

complete

GO:0060027

convergent extension involved in gastrulation

PMID:18159945[1]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-080801-1

P

Seeded From UniProt

complete

GO:0060028

convergent extension involved in axis elongation

PMID:24865967[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-070904-9

P

Seeded From UniProt

complete

GO:0060548

negative regulation of cell death

PMID:20493809[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060548

negative regulation of cell death

PMID:20493809[5]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-101026-4

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Jopling, C et al. (2007) Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 3 e225 PubMed GONUTS page
  2. 2.0 2.1 Paardekooper Overman, J et al. (2014) PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice. Mol. Cell. Biol. 34 2874-89 PubMed GONUTS page
  3. Razzaque, MA et al. (2007) Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat. Genet. 39 1013-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 Bonetti, M et al. (2014) Distinct and overlapping functions of ptpn11 genes in Zebrafish development. PLoS ONE 9 e94884 PubMed GONUTS page
  5. 5.0 5.1 Stewart, RA et al. (2010) Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev. Cell 18 750-62 PubMed GONUTS page