DANRE:Q6WGK5

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	prickle1a (ECO:0000313 with ZFIN:ZDB-GENE-030724-5) (synonyms: prickle1 (ECO:0000313 with ZFIN:ZDB-GENE-030724-5))
Protein Name(s)	Prickle1 (ECO:0000313 with EMBL:AAQ02633.1)
External Links
UniProt	Q6WGK5
EMBL	AY286492
RefSeq	NP_899185.2
UniGene	Dr.24985
ProteinModelPortal	Q6WGK5
STRING	7955.ENSDARP00000059513
GeneID	368249
KEGG	dre:368249
CTD	368249
ZFIN	ZDB-GENE-030724-5
HOVERGEN	HBG053679
KO	K04511
NextBio	20812830
GO	GO:0008270 GO:0060027 GO:0001764
Gene3D	2.10.110.10
InterPro	IPR010442 IPR001781
Pfam	PF00412 PF06297
SMART	SM00132
PROSITE	PS00478 PS50023 PS51303

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8UVJ6	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8UVJ6	P	Seeded From UniProt	complete
involved_in	GO:0071910	determination of liver left/right asymmetry	PMID:21215262^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110413-4	P	Seeded From UniProt	complete
involved_in	GO:0071907	determination of digestive tract left/right asymmetry	PMID:21215262^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110413-4	P	Seeded From UniProt	complete
involved_in	GO:0070121	Kupffer's vesicle development	PMID:20843857^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070316-4 ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0070121	Kupffer's vesicle development	PMID:20843857^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-081220-3	P	Seeded From UniProt	complete
involved_in	GO:0070121	Kupffer's vesicle development	PMID:20843857^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:22615492^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-120802-1 ZFIN:ZDB-MRPHLNO-120802-2	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7 ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7 ZFIN:ZDB-MRPHLNO-080929-3	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-263 ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:18976727^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042074	cell migration involved in gastrulation	PMID:12874125^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035622	intrahepatic bile duct development	PMID:21215262^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-051214-2 ZFIN:ZDB-MRPHLNO-110413-4	P	Seeded From UniProt	complete
involved_in	GO:0035622	intrahepatic bile duct development	PMID:21215262^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-020104-1 ZFIN:ZDB-MRPHLNO-110413-4	P	Seeded From UniProt	complete
involved_in	GO:0035622	intrahepatic bile duct development	PMID:21215262^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110413-4	P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:23324328^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-081220-3	P	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:23324328^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0021535	cell migration in hindbrain	PMID:17392791^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1367	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1037	P	Seeded From UniProt	complete
involved_in	GO:0003407	neural retina development	PMID:23324328^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:20843857^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-070316-4 ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:20843857^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-081220-3	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:20843857^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:12874125^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENO-980202-263	P	Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:24067530^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7 ZFIN:ZDB-MRPHLNO-140225-8	P	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000132	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010442	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Carreira-Barbosa, F et al. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 130 4037-46 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Cui, S et al. (2011) Disruption of planar cell polarity activity leads to developmental biliary defects. Dev. Biol. 351 229-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Oteiza, P et al. (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development 137 3459-68 PubMed GONUTS page
↑ Liu, X et al. (2012) MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation. Mol. Cell. Biol. 32 2934-42 PubMed GONUTS page
↑ ^5.0 ^5.1 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page
↑ Bassuk, AG et al. (2008) A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am. J. Hum. Genet. 83 572-81 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Mei, X et al. (2013) Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Dis Model Mech 6 679-88 PubMed GONUTS page
↑ Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page
↑ Jerber, J et al. (2014) The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Hum. Mol. Genet. 23 563-77 PubMed GONUTS page

[PMID:12874125-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Carreira-Barbosa, F et al. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development 130 4037-46 PubMed GONUTS page

[PMID:21215262-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Cui, S et al. (2011) Disruption of planar cell polarity activity leads to developmental biliary defects. Dev. Biol. 351 229-41 PubMed GONUTS page

[PMID:20843857-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Oteiza, P et al. (2010) Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ. Development 137 3459-68 PubMed GONUTS page

[PMID:22615492-4] Liu, X et al. (2012) MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating c-Jun N-terminal kinase 2 phosphorylation. Mol. Cell. Biol. 32 2934-42 PubMed GONUTS page

[PMID:18539122-5] 5.0 ^5.1 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page

[PMID:18976727-6] Bassuk, AG et al. (2008) A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am. J. Hum. Genet. 83 572-81 PubMed GONUTS page

[PMID:23324328-7] 7.0 ^7.1 ^7.2 Mei, X et al. (2013) Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis. Dis Model Mech 6 679-88 PubMed GONUTS page

[PMID:17392791-8] Tawk, M et al. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature 446 797-800 PubMed GONUTS page

[PMID:24067530-9] Jerber, J et al. (2014) The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Hum. Mol. Genet. 23 563-77 PubMed GONUTS page

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DANRE:Q6WGK5

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