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DANRE:Q6IVB6

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) No Information Provided.
Protein Name(s) Tyrosine hydroxylase 2 (ECO:0000313 with EMBL:AAT46027.1)

Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000103556)

External Links
UniProt Q6IVB6
EMBL BX510924
AY620823
RefSeq NP_001001829.1
UniGene Dr.88913
SMR Q6IVB6
Ensembl ENSDART00000109299
GeneID 414844
KEGG dre:414844
CTD 414844
ZFIN ZDB-GENE-050201-1
GeneTree ENSGT00390000010268
HOGENOM HOG000233373
HOVERGEN HBG006841
NextBio 20818740
Proteomes UP000000437
GO GO:0005506
GO:0016714
GO:0009072
Gene3D 1.10.800.10
InterPro IPR001273
IPR018301
IPR019774
IPR019773
PANTHER PTHR11473
Pfam PF00351
PIRSF PIRSF000336
PRINTS PR00372
SUPFAM SSF56534
PROSITE PS00367
PS51410

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0042427

serotonin biosynthetic process

PMID:23754283[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-130910-3

P

Seeded From UniProt

complete

involved_in

GO:0042416

dopamine biosynthetic process

PMID:27539857[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-150831-5
ZFIN:ZDB-MRPHLNO-150831-6

P

Seeded From UniProt

complete

enables

GO:0004510

tryptophan 5-monooxygenase activity

PMID:23754283[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853
WB:WBGene00000296

C

Seeded From UniProt

complete

involved_in

GO:0006585

dopamine biosynthetic process from tyrosine

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN001690342
RGD:3853

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98735
PANTHER:PTN000158532
RGD:3853
UniProtKB:P07101
UniProtKB:Q9PU40

C

Seeded From UniProt

complete

enables

GO:0004511

tyrosine 3-monooxygenase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000158532
RGD:3853
UniProtKB:P07101
UniProtKB:Q9PU40
WB:WBGene00000296
ZFIN:ZDB-GENE-990621-5

F

Seeded From UniProt

complete

enables

GO:0004497

monooxygenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

enables

GO:0005506

iron ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

F

Seeded From UniProt

complete

involved_in

GO:0009072

aromatic amino acid family metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0016714

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019773
InterPro:IPR019774

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001273
InterPro:IPR018301
InterPro:IPR019773
InterPro:IPR019774
InterPro:IPR036951

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ren, G et al. (2013) Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. J. Biol. Chem. 288 22451-9 PubMed GONUTS page
  2. Chen, YC et al. (2016) A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity. J. Biol. Chem. 291 21880-21892 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page