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DANRE:Q571R1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) gh1 (ECO:0000313 with ZFIN:ZDB-GENE-030725-2)
Protein Name(s) Growth hormone (ECO:0000313 with EMBL:CAI79040.1)
External Links
UniProt Q571R1
EMBL AJ937858
UniGene Dr.30452
ProteinModelPortal Q571R1
STRING 7955.ENSDARP00000055674
ZFIN ZDB-GENE-030725-2
HOVERGEN HBG011318
PhylomeDB Q571R1
GO GO:0005576
GO:0060612
GO:0050996
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR001400
IPR018116
PANTHER PTHR11417
Pfam PF00103
PRINTS PR00836
SUPFAM SSF47266
PROSITE PS00266
PS00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0070186

growth hormone activity

PMID:25333966[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060612

adipose tissue development

PMID:23456361[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-130701-1

P

Seeded From UniProt

complete

involved_in

GO:0050996

positive regulation of lipid catabolic process

PMID:23456361[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-130701-1

P

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

PMID:25333966[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070186

growth hormone activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002261645
ZFIN:ZDB-GENE-030725-2

F

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151829
UniProtKB:P01236
UniProtKB:P01241

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151829
UniProtKB:P01246

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:1858413
MGI:MGI:95707
MGI:MGI:97606
MGI:MGI:97607
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2429
RGD:2686
UniProtKB:P01238
UniProtKB:P01239
UniProtKB:P01241
UniProtKB:P01246
UniProtKB:P08998
UniProtKB:P14676

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2686

F

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002261645
ZFIN:ZDB-GENE-030725-2

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0070186

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0070186

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034975

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116
InterPro:IPR034975

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034975

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Li, M et al. (2014) Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology 155 4818-30 PubMed GONUTS page
  2. 2.0 2.1 McMenamin, SK et al. (2013) Dwarfism and increased adiposity in the gh1 mutant zebrafish vizzini. Endocrinology 154 1476-87 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page