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DANRE:Q288P2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) bmpr2b (ECO:0000313 with ZFIN:ZDB-GENE-070618-2)
Protein Name(s) BMP type IIb receptor (ECO:0000313 with EMBL:AAY45945.1)
External Links
UniProt Q288P2
EMBL DQ002899
RefSeq NP_001034896.1
UniGene Dr.134746
ProteinModelPortal Q288P2
SMR Q288P2
GeneID 555655
KEGG dre:555655
CTD 555655
ZFIN ZDB-GENE-070618-2
HOGENOM HOG000043088
HOVERGEN HBG050705
KO K04671
PhylomeDB Q288P2
NextBio 20881097
GO GO:0016021
GO:0005524
GO:0004702
GO:0005024
GO:0030509
GO:0007368
GO:0003146
GO:0001947
GO:0048570
InterPro IPR000472
IPR015770
IPR011009
IPR000719
IPR017441
IPR000333
PANTHER PTHR23255
PTHR23255:SF63
Pfam PF01064
PF00069
SUPFAM SSF56112
PROSITE PS00107
PS50011

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0048570

notochord morphogenesis

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

PMID:18222420[1]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-6
ZFIN:ZDB-MRPHLNO-080722-8

P

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-8

P

Seeded From UniProt

complete

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:18222420[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0003146

heart jogging

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-8

P

Seeded From UniProt

complete

involved_in

GO:0003146

heart jogging

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-7

P

Seeded From UniProt

complete

involved_in

GO:0002040

sprouting angiogenesis

PMID:25584797[2]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-070618-1

P

Seeded From UniProt

complete

involved_in

GO:0002040

sprouting angiogenesis

PMID:25584797[2]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-030131-7745
ZFIN:ZDB-GENE-070618-1

P

Seeded From UniProt

complete

involved_in

GO:0002040

sprouting angiogenesis

PMID:25584797[2]

ECO:0000316

genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENE-030131-1571
ZFIN:ZDB-GENE-070618-1

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-8

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:18222420[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-080722-7

P

Seeded From UniProt

complete

involved_in

GO:0001945

lymph vessel development

PMID:24608800[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-110729-3

P

Seeded From UniProt

complete

enables

GO:0098821

BMP receptor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1095407
PANTHER:PTN001147423

F

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:621789
UniProtKB:O00238
UniProtKB:P36894
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771

F

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000583675
UniProtKB:P27037
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:P37173
UniProtKB:Q13705

C

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102806
MGI:MGI:87911
MGI:MGI:87912
PANTHER:PTN000583675
RGD:71082
UniProtKB:P36896
UniProtKB:P36897
UniProtKB:Q13705
UniProtKB:Q8NER5

F

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1338938
MGI:MGI:87912
PANTHER:PTN000583675

P

Seeded From UniProt

complete

involved_in

GO:0007179

transforming growth factor beta receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003716
MGI:MGI:1338946
MGI:MGI:87911
MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
RGD:3852
RGD:620200
RGD:69651
RGD:70964
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
UniProtKB:Q04771
UniProtKB:Q06900
UniProtKB:Q90ZK6

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87911
PANTHER:PTN000583675
RGD:69651
RGD:70964
UniProtKB:P36896
UniProtKB:P37023
UniProtKB:Q04771
UniProtKB:Q13873

C

Seeded From UniProt

complete

enables

GO:0005026

transforming growth factor beta receptor activity, type II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001147423
RGD:70964

F

Seeded From UniProt

complete

enables

GO:0005024

transforming growth factor beta-activated receptor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98728
MGI:MGI:98729
PANTHER:PTN000583675
UniProtKB:A0A0B4KG59
UniProtKB:P36897
UniProtKB:P37023
UniProtKB:P37173
ZFIN:ZDB-GENE-070618-1

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

F

Seeded From UniProt

complete

enables

GO:0004675

transmembrane receptor protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000472

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719

P

Seeded From UniProt

complete

involved_in

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000333
InterPro:IPR000472

C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Monteiro, R et al. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev. Biol. 315 55-71 PubMed GONUTS page
  2. 2.0 2.1 2.2 Wakayama, Y et al. (2015) Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Dev. Cell 32 109-22 PubMed GONUTS page
  3. Kim, JD & Kim, J (2014) Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol. Cells 37 270-4 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page