DANRE:Q288P2

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	bmpr2b (ECO:0000313 with ZFIN:ZDB-GENE-070618-2)
Protein Name(s)	BMP type IIb receptor (ECO:0000313 with EMBL:AAY45945.1)
External Links
UniProt	Q288P2
EMBL	DQ002899
RefSeq	NP_001034896.1
UniGene	Dr.134746
ProteinModelPortal	Q288P2
SMR	Q288P2
GeneID	555655
KEGG	dre:555655
CTD	555655
ZFIN	ZDB-GENE-070618-2
HOGENOM	HOG000043088
HOVERGEN	HBG050705
KO	K04671
PhylomeDB	Q288P2
NextBio	20881097
GO	GO:0016021 GO:0005524 GO:0004702 GO:0005024 GO:0030509 GO:0007368 GO:0003146 GO:0001947 GO:0048570
InterPro	IPR000472 IPR015770 IPR011009 IPR000719 IPR017441 IPR000333
PANTHER	PTHR23255 PTHR23255:SF63
Pfam	PF01064 PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0048570	notochord morphogenesis	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18222420^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-6 ZFIN:ZDB-MRPHLNO-080722-8	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-8	P	Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:18222420^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-8	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-7	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:25584797^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-070618-1	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:25584797^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030131-7745 ZFIN:ZDB-GENE-070618-1	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:25584797^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-GENE-030131-1571 ZFIN:ZDB-GENE-070618-1	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-8	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:18222420^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080722-7	P	Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	PMID:24608800^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110729-3	P	Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1095407 PANTHER:PTN001147423	F	Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C	Seeded From UniProt	complete
enables	GO:0005026	transforming growth factor beta receptor activity, type II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147423 RGD:70964	F	Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P	Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Monteiro, R et al. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev. Biol. 315 55-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Wakayama, Y et al. (2015) Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Dev. Cell 32 109-22 PubMed GONUTS page
↑ Kim, JD & Kim, J (2014) Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol. Cells 37 270-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18222420-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Monteiro, R et al. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev. Biol. 315 55-71 PubMed GONUTS page

[PMID:25584797-2] 2.0 ^2.1 ^2.2 Wakayama, Y et al. (2015) Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Dev. Cell 32 109-22 PubMed GONUTS page

[PMID:24608800-3] Kim, JD & Kim, J (2014) Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish. Mol. Cells 37 270-4 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:Q288P2

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