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DANRE:L1CA1

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) nadl1.1
Protein Name(s) Neural cell adhesion molecule L1.1

N-CAM-L1.1 NCAM-L1.1

External Links
UniProt Q90478
EMBL X89204
PIR T30581
UniGene Dr.75066
ProteinModelPortal Q90478
ZFIN ZDB-GENE-980526-512
eggNOG NOG293951
HOGENOM HOG000231380
HOVERGEN HBG000144
InParanoid Q90478
PhylomeDB Q90478
PRO PR:Q90478
Proteomes UP000000437
GO GO:0016021
GO:0005886
GO:0007411
GO:0007155
GO:0042552
GO:0007422
GO:0050808
GO:0019226
Gene3D 2.60.40.10
InterPro IPR003961
IPR007110
IPR013783
IPR013098
IPR003599
IPR003598
IPR026966
IPR026965
PANTHER PTHR10489:SF41
Pfam PF13882
PF00041
PF07679
SMART SM00060
SM00409
SM00408
SUPFAM SSF49265
PROSITE PS50853
PS50835

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q9I8G3


P

Phenotypically, nadl1.1 morphants are similar to alcama morphants: by 5 dpf they have a protruding lower jaw, cardiac edema and absent swim bladder (data not shown). Alcian blue staining reveals cartilage defects reminiscent of alcama morphants: mc and ch are changed in orientation and are fused to pq and hm, respectively (Fig. 6G–H'). Injection of nadl1.1 MO into p53−/− mutants yields similar percentages of larvae with dlx5a down-regulation and jaw abnormalities (Fig. 6F, I), indicating that the observed effect is specific to nadl1.1 knockdown.

complete
CACAO 2074

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Similar to alcama MO, nadl1.1MOaffects edn1-dependent gene expression: hand2 and dlx5a expression is strongly reduced in the arches with a more pronounced effect on the posterior arches (Fig. 6B–E).

complete
CACAO 2075

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0007411

axon guidance

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026965

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026965

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:21073867[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0019226

transmission of nerve impulse

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026965

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0042552

myelination

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026965

P

Seeded From UniProt

complete

GO:0044295

axonal growth cone

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q05695

C

Seeded From UniProt

complete

GO:0045773

positive regulation of axon extension

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q05695

P

Seeded From UniProt

complete

GO:0050808

synapse organization

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026965

P

Seeded From UniProt

complete

GO:0060536

cartilage morphogenesis

PMID:21073867[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q9I8G3

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Choudhry, P et al. (2011) Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev. Biol. 349 483-93 PubMed GONUTS page