DANRE:L1CA1

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	nadl1.1
Protein Name(s)	Neural cell adhesion molecule L1.1 N-CAM-L1.1 NCAM-L1.1
External Links
UniProt	Q90478
EMBL	X89204
PIR	T30581
UniGene	Dr.75066
ProteinModelPortal	Q90478
ZFIN	ZDB-GENE-980526-512
eggNOG	NOG293951
HOGENOM	HOG000231380
HOVERGEN	HBG000144
InParanoid	Q90478
PhylomeDB	Q90478
PRO	PR:Q90478
Proteomes	UP000000437
GO	GO:0016021 GO:0005886 GO:0007411 GO:0007155 GO:0042552 GO:0007422 GO:0050808 GO:0019226
Gene3D	2.60.40.10
InterPro	IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR026966 IPR026965
PANTHER	PTHR10489:SF41
Pfam	PF13882 PF00041 PF07679
SMART	SM00060 SM00409 SM00408
SUPFAM	SSF49265
PROSITE	PS50853 PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060536	cartilage morphogenesis	PMID:21073867	ECO:0000316		UniProtKB:Q9I8G3	P		Phenotypically, nadl1.1 morphants are similar to alcama morphants: by 5 dpf they have a protruding lower jaw, cardiac edema and absent swim bladder (data not shown). Alcian blue staining reveals cartilage defects reminiscent of alcama morphants: mc and ch are changed in orientation and are fused to pq and hm, respectively (Fig. 6G–H'). Injection of nadl1.1 MO into p53−/− mutants yields similar percentages of larvae with dlx5a down-regulation and jaw abnormalities (Fig. 6F, I), indicating that the observed effect is specific to nadl1.1 knockdown.	complete CACAO 2074
	GO:0010628	positive regulation of gene expression	PMID:21073867	ECO:0000315			P		Similar to alcama MO, nadl1.1MOaffects edn1-dependent gene expression: hand2 and dlx5a expression is strongly reduced in the arches with a more pronounced effect on the posterior arches (Fig. 6B–E).	complete CACAO 2075
part_of	GO:0044295	axonal growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05695	C		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05695	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21073867	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060536	cartilage morphogenesis	PMID:21073867	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9I8G3	P		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	PMID:15356195	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050628-1	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
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References

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