DANRE:INVS

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	invs
Protein Name(s)	Inversin
External Links
UniProt	Q8UVC1
EMBL	AF465261
RefSeq	NP_694502.1
UniGene	Dr.32732
ProteinModelPortal	Q8UVC1
PRIDE	Q8UVC1
GeneID	245946
KEGG	dre:245946
CTD	27130
ZFIN	ZDB-GENE-020507-2
eggNOG	COG0666
HOGENOM	HOG000234066
HOVERGEN	HBG083788
InParanoid	Q8UVC1
NextBio	20797199
PRO	PR:Q8UVC1
Proteomes	UP000000437
GO	GO:0005737 GO:0005856 GO:0007275 GO:0016055
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR000048
Pfam	PF00023 PF12796
SMART	SM00248 SM00015
SUPFAM	SSF48403
PROSITE	PS50297 PS50088 PS50096

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005929	cilium	PMID:21602787^[1]	ECO:0000314			C	Figure 5- b9d2 and fleer contribute to the ciliary localization of Inversin.	complete CACAO 8033
part_of	GO:0005929	cilium	PMID:21602787^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0072116	pronephros formation	PMID:22687244^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3 ZFIN:ZDB-MRPHLNO-120809-2	P	Seeded From UniProt	complete
involved_in	GO:0072114	pronephros morphogenesis	PMID:26904945^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050727-1 ZFIN:ZDB-MRPHLNO-160801-3	P	Seeded From UniProt	complete
involved_in	GO:0072114	pronephros morphogenesis	PMID:21498478^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110808-1	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3 ZFIN:ZDB-MRPHLNO-080929-4	P	Seeded From UniProt	complete
involved_in	GO:0060027	convergent extension involved in gastrulation	PMID:18539122^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-060209-7 ZFIN:ZDB-MRPHLNO-080929-3	P	Seeded From UniProt	complete
involved_in	GO:0036372	opsin transport	PMID:21602787^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3 ZFIN:ZDB-MRPHLNO-120402-3	P	Seeded From UniProt	complete
involved_in	GO:0036372	opsin transport	PMID:21602787^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080107-2 ZFIN:ZDB-MRPHLNO-080929-3	P	Seeded From UniProt	complete
involved_in	GO:0036372	opsin transport	PMID:21602787^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3	P	Seeded From UniProt	complete
involved_in	GO:0035844	cloaca development	PMID:21498478^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110808-1	P	Seeded From UniProt	complete
involved_in	GO:0010171	body morphogenesis	PMID:12872123^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:22687244^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:22687244^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-080929-3 ZFIN:ZDB-MRPHLNO-120809-2	P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:15852005^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-050727-1	P	Seeded From UniProt	complete
involved_in	GO:0001736	establishment of planar polarity	PMID:21602787^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-041217-5 ZFIN:ZDB-MRPHLNO-120402-3	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Zhao, C & Malicki, J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 30 2532-44 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Fukui, H et al. (2012) The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish. FEBS Lett. 586 2273-9 PubMed GONUTS page
↑ Jaffe, KM et al. (2016) c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep 14 1841-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Burcklé, C et al. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum. Mol. Genet. 20 2611-27 PubMed GONUTS page
↑ ^5.0 ^5.1 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page
↑ Otto, EA et al. (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat. Genet. 34 413-20 PubMed GONUTS page
↑ Simons, M et al. (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat. Genet. 37 537-43 PubMed GONUTS page

[PMID:21602787-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Zhao, C & Malicki, J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 30 2532-44 PubMed GONUTS page

[PMID:22687244-2] 2.0 ^2.1 ^2.2 Fukui, H et al. (2012) The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish. FEBS Lett. 586 2273-9 PubMed GONUTS page

[PMID:26904945-3] Jaffe, KM et al. (2016) c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep 14 1841-9 PubMed GONUTS page

[PMID:21498478-4] 4.0 ^4.1 Burcklé, C et al. (2011) Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum. Mol. Genet. 20 2611-27 PubMed GONUTS page

[PMID:18539122-5] 5.0 ^5.1 Kishimoto, N et al. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14 954-61 PubMed GONUTS page

[PMID:12872123-6] Otto, EA et al. (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat. Genet. 34 413-20 PubMed GONUTS page

[PMID:15852005-7] Simons, M et al. (2005) Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat. Genet. 37 537-43 PubMed GONUTS page

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DANRE:INVS

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