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DANRE:IFT56

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) ttc26 (synonyms: ift56 (ECO:0000303 with PMID:24596149[1]))
Protein Name(s) Intraflagellar transport protein 56 (ECO:0000303 with PMID:24596149[1])

Tetratricopeptide repeat protein 26 TPR repeat protein 26

External Links
UniProt Q5PR66
EMBL AL954384
BC086810
RefSeq NP_001008617.1
UniGene Dr.14525
STRING 7955.ENSDARP00000032176
PaxDb Q5PR66
Ensembl ENSDART00000032494
GeneID 494074
KEGG dre:494074
CTD 79989
ZFIN ZDB-GENE-041212-41
eggNOG KOG3785
ENOG410XRMP
GeneTree ENSGT00390000000159
HOGENOM HOG000258854
HOVERGEN HBG108610
InParanoid Q5PR66
KO K19685
OMA VEYMIRI
OrthoDB EOG091G04RS
Reactome [www.reactome.org/content/detail/R-DRE-5620924 R-DRE-5620924]
PRO PR:Q5PR66
Proteomes UP000000437
Bgee ENSDARG00000012039
GO GO:0005929
GO:0030992
GO:0060271
GO:0042073
GO:0046530
GO:0008594
GO:0035845
GO:0039023
GO:0007224
Gene3D 1.25.40.10
InterPro IPR013026
IPR011990
IPR019734
IPR030511
PANTHER PTHR14781:SF1
SMART SM00028
SUPFAM SSF48452
PROSITE PS50293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0031514

motile cilium

PMID:24596149[1]

ECO:0000315

C

Organism: Danio rerio Protein: TTC26/DYF13 // ttc26 Figure 2: "These findings demonstrate that TTC26 is important for cilia motility." and show that the ttc26 is localized in the motile cilium.

complete
CACAO 12861

GO:0044458

motile cilium assembly

PMID:24596149[1]

ECO:0000315

P

Organism: Danio rerio Protein: TTC26/DYF13 // Ttc26 Figure 3: "Thus, in both zebrafish and C. reinhardtii, TTC26/DYF13 is required for assembly of full-length cilia with normal functions." and the tested cilia were motile.

complete
CACAO 12863

involved_in

GO:0061512

protein localization to cilium

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BS45

P

Seeded From UniProt

complete

involved_in

GO:0035082

axoneme assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BS45

P

Seeded From UniProt

complete

involved_in

GO:0042073

intraciliary transport

PMID:24596149[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BS45

C

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q8BS45

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:24596149[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-3

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-4

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-3

P

Seeded From UniProt

complete

involved_in

GO:0039023

pronephric duct morphogenesis

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-4

P

Seeded From UniProt

complete

involved_in

GO:0039023

pronephric duct morphogenesis

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-3

P

Seeded From UniProt

complete

involved_in

GO:0035845

photoreceptor cell outer segment organization

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-4

P

Seeded From UniProt

complete

involved_in

GO:0035845

photoreceptor cell outer segment organization

PMID:22718903[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-120906-3

P

Seeded From UniProt

complete

enables

GO:0120170

intraciliary transport particle B binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369

F

Seeded From UniProt

complete

part_of

GO:0097546

ciliary base

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

involved_in

GO:0035735

intraciliary transport involved in cilium assembly

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

P

Seeded From UniProt

complete

involved_in

GO:0035720

intraciliary anterograde transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:Q57ZL2

P

Seeded From UniProt

complete

part_of

GO:0031514

motile cilium

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000381369
UniProtKB:A8JA42

C

Seeded From UniProt

complete

part_of

GO:0030992

intraciliary transport particle B

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2444853
PANTHER:PTN000381369
UniProtKB:A8JA42
UniProtKB:Q57ZL2

C

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:22718903[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046530

photoreceptor cell differentiation

PMID:22718903[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008594

photoreceptor cell morphogenesis

PMID:22718903[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0969
UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ishikawa, H et al. (2014) TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Elife 3 e01566 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Zhang, Q et al. (2012) Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Mol. Biol. Cell 23 3069-78 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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