DANRE:CCD40

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	ccdc40 (synonyms: lok)
Protein Name(s)	Coiled-coil domain-containing protein 40 Protein locke
External Links
UniProt	Q56A40
EMBL	BX005286 CR854963 BC092181
RefSeq	NP_001258742.1
UniGene	Dr.157455 Dr.25001
Ensembl	ENSDART00000002617 ENSDART00000145154
GeneID	568590
KEGG	dre:568590
CTD	55036
ZFIN	ZDB-GENE-060503-723
eggNOG	NOG138528
GeneTree	ENSGT00440000035688
HOGENOM	HOG000111411
InParanoid	Q56A40
OMA	TTQAEGQ
OrthoDB	EOG747PHC
PhylomeDB	Q56A40
TreeFam	TF325559
Proteomes	UP000000437
Bgee	Q56A40
GO	GO:0005929 GO:0005737 GO:0070286 GO:0035082 GO:0042384 GO:0003341 GO:0007368 GO:0003143 GO:0003351 GO:0060287 GO:0003146 GO:0001947 GO:0048793
InterPro	IPR013956
Pfam	PF08647

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070286	axonemal dynein complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G0X9	P	Seeded From UniProt	complete
involved_in	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BI79	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BI79	C	Seeded From UniProt	complete
involved_in	GO:0003341	cilium movement	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-3	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-2	P	Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:17576052^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-956	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-543	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1297	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:9007249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-105	P	Seeded From UniProt	complete
involved_in	GO:0048793	pronephros development	PMID:17576052^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	PMID:17576052^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9334285^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-3	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-2	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:17576052^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0003351	epithelial cilium movement	PMID:17576052^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0003341	cilium movement	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-3	P	Seeded From UniProt	complete
involved_in	GO:0003341	cilium movement	PMID:21131974^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-MRPHLNO-110125-2	P	Seeded From UniProt	complete
involved_in	GO:0003146	heart jogging	PMID:9334285^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	PMID:9334285^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:9334285^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	ZFIN:ZDB-GENO-980202-1298	P	Seeded From UniProt	complete
involved_in	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443893 PANTHER:PTN000780552 UniProtKB:Q4G0X9 ZFIN:ZDB-GENE-060503-723	P	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443893 PANTHER:PTN000780552	P	Seeded From UniProt	complete
part_of	GO:0005930	axoneme	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000780552 UniProtKB:Q4G0X9	C	Seeded From UniProt	complete
involved_in	GO:0035082	axoneme assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037386	P	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Becker-Heck, A et al. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat. Genet. 43 79-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Zhao, C & Malicki, J (2007) Genetic defects of pronephric cilia in zebrafish. Mech. Dev. 124 605-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Chen, JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 293-302 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21131974-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Becker-Heck, A et al. (2011) The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. Nat. Genet. 43 79-84 PubMed GONUTS page

[PMID:17576052-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Zhao, C & Malicki, J (2007) Genetic defects of pronephric cilia in zebrafish. Mech. Dev. 124 605-16 PubMed GONUTS page

[PMID:9007249-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Chen, JN et al. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123 293-302 PubMed GONUTS page

[PMID:9334285-4] 4.0 ^4.1 ^4.2 ^4.3 Chen, JN et al. (1997) Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development 124 4373-82 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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DANRE:CCD40

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