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DANRE:B3DHL9

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) kcnh1a (ECO:0000313 with ZFIN:ZDB-GENE-061226-1)
Protein Name(s) Potassium voltage-gated channel, subfamily H (Eag-related), member 1 (ECO:0000313 with EMBL:AAI62812.1)
External Links
UniProt B3DHL9
EMBL BC162812
UniGene Dr.30012
ProteinModelPortal B3DHL9
STRING 7955.ENSDARP00000031629
ZFIN ZDB-GENE-061226-1
eggNOG COG2202
HOGENOM HOG000230794
HOVERGEN HBG101348
GO GO:0016021
GO:0000155
GO:0005249
Gene3D 2.60.120.10
InterPro IPR018490
IPR000595
IPR030170
IPR005821
IPR003949
IPR003938
IPR001610
IPR000014
IPR000700
IPR014710
PANTHER PTHR10217:SF377
Pfam PF00027
PF00520
PF13426
PRINTS PR01463
PR01464
SMART SM00100
SM00086
SM00091
SUPFAM SSF51206
SSF55785
TIGRFAMs TIGR00229
PROSITE PS50042
PS50113
PS50112

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006355

regulation of transcription, DNA-dependent

PMID:22927438[1]

IMP: Inferred from Mutant Phenotype

P

Figure 6B shows early gene expression is modulated by kcnh1 following transcription.

complete
CACAO 5655

GO:0005249

voltage-gated potassium channel activity

PMID:22927438[1]

IDA: Inferred from Direct Assay

F

Figure 2 shows that when expressed in Xenopus oocytes, kcnh1 responds to applied voltage and allows a potassium ion current to flow.

complete
CACAO 5954

GO:0007498

mesoderm development

PMID:22927438[1]

IMP: Inferred from Mutant Phenotype

P

Figure 6A shows reduced mesoderm in mutants

complete
CACAO 5973

GO:0010467

gene expression

PMID:22927438[1]

IMP: Inferred from Mutant Phenotype

P

Figure 6b shows alterations in the levels of gene expression.

complete
CACAO 6081

GO:0000155

phosphorelay sensor kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

F

Seeded From UniProt

complete

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

P

Seeded From UniProt

complete

GO:0005216

ion channel activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

F

Seeded From UniProt

complete

GO:0005249

voltage-gated potassium channel activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938
InterPro:IPR003949
InterPro:IPR030170

F

Seeded From UniProt

complete

GO:0005249

voltage-gated potassium channel activity

PMID:22927438[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030170

C

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:22927438[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

P

Seeded From UniProt

complete

GO:0006811

ion transport

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

GO:0006813

potassium ion transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938
InterPro:IPR003949

P

Seeded From UniProt

complete

GO:0007498

mesoderm development

PMID:22927438[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008076

voltage-gated potassium channel complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030170

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003938
InterPro:IPR003949
InterPro:IPR005821

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0023014

signal transduction by protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000700

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005821

P

Seeded From UniProt

complete

GO:0071805

potassium ion transmembrane transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR030170

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Stengel, R et al. (2012) Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. J. Biol. Chem. 287 35565-75 PubMed GONUTS page