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DANRE:B0R0V8
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Uncharacterized protein (ECO:0000313 with Ensembl:ENSDARP00000113453) | |
| External Links | ||
| UniProt | B0R0V8 | |
| EMBL | AL929096 AL929271 | |
| RefSeq | NP_001278637.1 | |
| UniGene | Dr.7421 | |
| Ensembl | ENSDART00000099043 ENSDART00000145681 | |
| GeneID | 286779 | |
| KEGG | dre:286779 | |
| CTD | 51606 | |
| ZFIN | ZDB-GENE-021219-2 | |
| eggNOG | COG5231 | |
| GeneTree | ENSGT00390000003289 | |
| HOGENOM | HOG000007240 | |
| HOVERGEN | HBG000459 | |
| KO | K02144 | |
| OMA | DTLQENH | |
| Reactome | REACT_201955 REACT_220329 REACT_246915 | |
| PRO | PR:B0R0V8 | |
| Proteomes | UP000000437 | |
| GO | GO:0000221 GO:0046961 GO:0015991 GO:0060041 | |
| Gene3D | 1.25.10.10 1.25.40.150 | |
| InterPro | IPR011989 IPR016024 IPR004908 IPR011987 | |
| PANTHER | PTHR10698 | |
| Pfam | PF11698 PF03224 | |
| PIRSF | PIRSF032184 | |
| SUPFAM | SSF48371 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0061075 |
positive regulation of neural retina development |
ECO:0000315 |
P |
Fig. 7 and Fig. 8 show that the v-ATPase mutants display defects in cell proliferation and increased levels of apoptosis which demonstrates its role in the proper development of the neural retina. |
complete | |||||
| GO:0048069 |
positive regulation of eye pigmentation |
ECO:0000315 |
P |
Fig 5 |
complete | |||||
|
involved_in |
GO:0048069 |
eye pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061075 |
positive regulation of neural retina development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060348 |
bone development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-170313-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-020426-40 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043473 |
pigmentation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-131101-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030282 |
bone mineralization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-170313-2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015991 |
ATP hydrolysis coupled proton transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000759775 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015991 |
ATP hydrolysis coupled proton transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000759775 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000759775 |
F |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Nuckels, RJ et al. (2009) The vacuolar-ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye. Invest. Ophthalmol. Vis. Sci. 50 893-905 PubMed GONUTS page
- ↑ 2.0 2.1 Zhang, Y et al. (2017) ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 13 e1006481 PubMed GONUTS page
- ↑ Gross, JM et al. (2005) Identification of zebrafish insertional mutants with defects in visual system development and function. Genetics 170 245-61 PubMed GONUTS page
- ↑ Dooley, CM et al. (2013) Slc45a2 and V-ATPase are regulators of melanosomal pH homeostasis in zebrafish, providing a mechanism for human pigment evolution and disease. Pigment Cell Melanoma Res 26 205-17 PubMed GONUTS page
