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DANRE:A0A060IVL7

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) TRIM69 (ECO:0000313 with EMBL:AIC36826.1)
Protein Name(s) Tripartite motif containing 69 protein (ECO:0000313 with EMBL:AIC36826.1)
External Links
UniProt A0A060IVL7
EMBL KJ603528
RefSeq NP_001289175.1
PaxDb A0A060IVL7
GeneID 101883816
KEGG dre:101883816
eggNOG ENOG410ITER
ENOG4111F4K
GO GO:0005622
GO:0008270
Gene3D 3.30.40.10
4.10.45.10
InterPro IPR001870
IPR003879
IPR013320
IPR006574
IPR003877
IPR000315
IPR018957
IPR001841
IPR013083
IPR017907
Pfam PF13765
PF00622
PF00643
PF00097
PRINTS PR01407
SMART SM00336
SM00589
SM00184
SM00449
SUPFAM SSF49899
PROSITE PS50188
PS50119
PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000315

C

Seeded From UniProt

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000315
InterPro:IPR001841

F

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

GO:0022004

midbrain-hindbrain boundary maturation during brain development

PMID:27050765[1]

IMP: Inferred from Mutant Phenotype

P

Decrease in Trim69 by Morpholino antisense oligonucleotides induced brain deformation particularly in the mid-hind brain boundary, as shown by figure 2 (a,b).

complete
CACAO 11644

GO:1900118

negative regulation of execution phase of apoptosis

PMID:2705076[2]

IGI: Inferred from Genetic Interaction

P

TUNEL assay analyses indicated that the human TRIM69 mRNA can also rescue the observed apoptosis induced by zebrafish trim69-MO. ALSO qPCR assay analyses indicated that the human trim69 mRNA can rescue the apoptosis induced by zebrafish trim69-MO.

Missing: with/from
CACAO 11707

GO:1904746

negative regulation of apoptotic process involved in development

PMID:27050765[1]

IMP: Inferred from Mutant Phenotype

P

Trim69-MO lead to a increased apoptotic cells when compared to Trim69. This will lead into a phenotypic degradation of the developing embryo brain in the zebrafish. shown in figure 2: "2(B) The examined apoptosis of zebrafish embryos by TUNEL assay. trim69-CON(e): control group; trim69-MO(f): trim69 knocking down; trim69-MO:trim69-mRNA(g): co-injection with trim69-MO and human trim69 mRNA; black arrow indicates apoptotic cells; scale bar: 200 μm."

complete
CACAO 11649

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Han, R et al. (2016) Trim69 regulates zebrafish brain development by ap-1 pathway. Sci Rep 6 24034 PubMed GONUTS page
  2. Sack, KE (1989) The day I ran without my watch. South. Med. J. 82 506 PubMed GONUTS page