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DANRE:A0A060IVL7
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | TRIM69 (ECO:0000313 with EMBL:AIC36826.1) | |
| Protein Name(s) | Tripartite motif containing 69 protein (ECO:0000313 with EMBL:AIC36826.1) | |
| External Links | ||
| UniProt | A0A060IVL7 | |
| EMBL | KJ603528 | |
| RefSeq | NP_001289175.1 | |
| PaxDb | A0A060IVL7 | |
| GeneID | 101883816 | |
| KEGG | dre:101883816 | |
| eggNOG | ENOG410ITER ENOG4111F4K | |
| GO | GO:0005622 GO:0008270 | |
| Gene3D | 3.30.40.10 4.10.45.10 | |
| InterPro | IPR001870 IPR003879 IPR013320 IPR006574 IPR003877 IPR000315 IPR018957 IPR001841 IPR013083 IPR017907 | |
| Pfam | PF13765 PF00622 PF00643 PF00097 | |
| PRINTS | PR01407 | |
| SMART | SM00336 SM00589 SM00184 SM00449 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50188 PS50119 PS00518 PS50089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0022004 |
midbrain-hindbrain boundary maturation during brain development |
ECO:0000315 |
P |
Decrease in Trim69 by Morpholino antisense oligonucleotides induced brain deformation particularly in the mid-hind brain boundary, as shown by figure 2 (a,b). |
complete | |||||
| GO:1900118 |
negative regulation of execution phase of apoptosis |
ECO:0000316 |
P |
TUNEL assay analyses indicated that the human TRIM69 mRNA can also rescue the observed apoptosis induced by zebrafish trim69-MO. ALSO qPCR assay analyses indicated that the human trim69 mRNA can rescue the apoptosis induced by zebrafish trim69-MO. |
Missing: with/from | |||||
| GO:1904746 |
negative regulation of apoptotic process involved in development |
ECO:0000315 |
P |
Trim69-MO lead to a increased apoptotic cells when compared to Trim69. This will lead into a phenotypic degradation of the developing embryo brain in the zebrafish. shown in figure 2: "2(B) The examined apoptosis of zebrafish embryos by TUNEL assay. trim69-CON(e): control group; trim69-MO(f): trim69 knocking down; trim69-MO:trim69-mRNA(g): co-injection with trim69-MO and human trim69 mRNA; black arrow indicates apoptotic cells; scale bar: 200 μm." |
complete | |||||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-160728-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-080908-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-160728-3 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Han, R et al. (2016) Trim69 regulates zebrafish brain development by ap-1 pathway. Sci Rep 6 24034 PubMed GONUTS page
- ↑ Sack, KE (1989) The day I ran without my watch. South. Med. J. 82 506 PubMed GONUTS page
- ↑ Han, R et al. (2016) A novel TRIM family member, Trim69, regulates zebrafish development through p53-mediated apoptosis. Mol. Reprod. Dev. 83 442-54 PubMed GONUTS page
