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Category:GO:1990620 ! ANPR-A receptor complex
name: ANPR-A receptor complex
namespace: cellular_component
def: "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, PMID:15117952]
comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay).
synonym: "NPR1 receptor complex" RELATED []
is_a: GO:0043235 ! receptor complex
AmiGO
<GOterm>GO:1990620</GOterm>
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