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Category:GO:1990618 ! obsolete ANPR-A:ANP complex
This GO term has been obsoleted.
Do not annotate to it.
id: GO:1990618
name: obsolete ANPR-A:ANP complex
namespace: cellular_component
def: "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, PMID:15117952]
comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay).
synonym: "ANPR-A:ANP complex" EXACT []
is_obsolete: true
AmiGO
<GOterm>GO:1990618</GOterm>
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