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Category:GO:1990513 ! CLOCK-BMAL transcription complex
name: CLOCK-BMAL transcription complex
namespace: cellular_component
def: "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, PMID:23229515]
comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
synonym: "CLOCK/BMAL complex" EXACT []
is_a: GO:0090575 ! RNA polymerase II transcription regulator complex
AmiGO
<GOterm>GO:1990513</GOterm>
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