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Category:GO:1990306 ! RSP5-BUL ubiquitin ligase complex
name: RSP5-BUL ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, PMID:9931424]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424
synonym: "RSP5-BUL1 complex" EXACT []
synonym: "RSP5-BUL2 complex" RELATED []
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1990234 ! transferase complex
AmiGO
<GOterm>GO:1990306</GOterm>
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