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Category:GO:1990302 ! Bre1-Rad6 ubiquitin ligase complex
name: Bre1-Rad6 ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, PMID:19531475]
comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
synonym: "Bre1-Rad6 complex" EXACT []
is_a: GO:1990234 ! transferase complex
relationship: part_of: GO:0005622 ! intracellular anatomical structure
AmiGO
<GOterm>GO:1990302</GOterm>
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