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Category:GO:1990231 ! STING complex

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DAG for GO:1990231id: GO:1990231

name: STING complex
namespace: cellular_component
def: "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]
synonym: "stimulator of interferon genes complex" EXACT [GOC:bhm, PMID:22705373, PMID:23910378]
is_a: GO:0098796 ! membrane protein complex
relationship: part_of: GO:0030659 ! cytoplasmic vesicle membrane

AmiGO <GOterm>GO:1990231</GOterm>
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