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Category:GO:0140943 ! histone H4K20 trimethyltransferase activity
name: histone H4K20 trimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H+ + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine. This reaction is the addition of three methyl groups to the lysine residue at position 20 of the histone H4 protein, producing histone H4K20me3." [RHEA:64456]
comment: Note that the residue position corresponds to the canonical human H4 histone (UniProtKB:P02309); this residue is conserved across all eukaryotes. Note that the initiation methionine is cleaved, so the first residue is S1.
synonym: "histone H4K20 trimethylase activity" EXACT []
synonym: "histone H4K20 trimethylation" EXACT []
synonym: "histone lysine N-trimethyltransferase activity (H4-K20 specific)" EXACT []
xref: EC:2.1.1.372
xref: RHEA:64456
is_a: GO:0042799 ! histone H4K20 methyltransferase activity
AmiGO
<GOterm>GO:0140943</GOterm>
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