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Category:GO:0140942 ! histone H3K9 dimethyltransferase activity
name: histone H3K9 dimethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2." [RHEA:64444]
comment: Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
synonym: "histone H3-K9 dimethylation" BROAD []
synonym: "histone H3K9 dimethylase activity" EXACT []
synonym: "histone H3K9 dimethylation" BROAD []
synonym: "histone H3K9 mono/dimethylase activity" EXACT []
synonym: "histone lysine N-dimethyltransferase activity (H3-K9 specific)" EXACT []
xref: EC:2.1.1.368
xref: RHEA:64444
is_a: GO:0046974 ! histone H3K9 methyltransferase activity
AmiGO
<GOterm>GO:0140942</GOterm>
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