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Category:GO:0120157 ! PAR polarity complex
name: PAR polarity complex
namespace: cellular_component
def: "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC." [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236]
comment: "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4.
synonym: "apical polarity complex" EXACT [GOC:lnp]
synonym: "BEM1-CDC24-CLA4 complex" NARROW []
synonym: "Cdc42p GEF-PAK complex" NARROW []
synonym: "PAR3-PAR6-atypical PKC" NARROW [GOC:lnp]
synonym: "PAR3/PAR6/aPKC" NARROW [GOC:lnp]
synonym: "PAR6-PAR3-aPKC complex" NARROW [PMID:18005931]
is_a: GO:1902554 ! serine/threonine protein kinase complex
AmiGO
<GOterm>GO:0120157</GOterm>
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