Category:GO:0120123 ! ubiquitin activating enzyme complex

name: ubiquitin activating enzyme complex
namespace: cellular_component
def: "A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:lnp, PMID:9545234]
synonym: "E1 complex" EXACT [GOC:lnp]
synonym: "E1 ubiquitin-activating enzyme" RELATED [GOC:lnp]
is_a: GO:0140535 ! intracellular protein-containing complex
is_a: GO:1902494 ! catalytic complex

AmiGO <GOterm>GO:0120123</GOterm>
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