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Category:GO:0110153 ! RNA NAD-cap (NMN-forming) hydrolase activity
name: RNA NAD-cap (NMN-forming) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+." [GOC:sp, PMID:25533955, PMID:31101919, RHEA:60876]
comment: This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.
xref: RHEA:60876
is_a: GO:0016462 ! pyrophosphatase activity
is_a: GO:0140098 ! catalytic activity, acting on RNA
AmiGO
<GOterm>GO:0110153</GOterm>
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