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Category:GO:0080007 ! S-nitrosoglutathione reductase (NADH) activity
name: S-nitrosoglutathione reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-nitrosoglutathione + NADH + H+ = S-(hydroxysulfenamide)glutathione + NAD+." [PMID:11260719, PMID:27094420, PMID:30795534]
comment: S-(hydroxysulfenamide)glutathione (GSNHOH) is an unstable intermediate. At high GSH levels, it is decomposed to glutathione disulfide (GSSG) and hydroxylamine. At low GSH levels, GSNHOH spontaneously converts to glutathione sulfinamid (GSONH2), which can be hydrolyzed to glutathione sulfinic acid (GSOOH) and ammonia. {xref="PMID:30795534"}
xref: MetaCyc:RXN-17884
xref: RHEA:78371
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AmiGO
<GOterm>GO:0080007</GOterm>
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