GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:GO:0070579 ! 5-methylcytosine dioxygenase activity
name: 5-methylcytosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC)." [PMID:19372391, PMID:21496894, PMID:21778364]
comment: This reaction removes the methyl group from position 5 of cytosine in DNA via oxidation of the 5-methylcytosine, followed by removal of the oxidated base by the base excision repair system. Do not confuse with oxidative DNA demethylase activity ; GO:0035516, which directly reverses the alkylation on nucleodides in the DNA.
synonym: "methylcytosine dioxygenase activity" BROAD []
xref: EC:1.14.11.80
xref: [ WIkipedia:DNA_demethylation]
is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity
AmiGO
<GOterm>GO:0070579</GOterm>
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Usage Notes
References
See Help:References for how to manage references in GONUTS.
Pages in category "GO:0070579 ! 5-methylcytosine dioxygenase activity"
This category contains only the following page.
