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Category:GO:0070549 ! siRNA-mediated gene silencing by inhibition of translation
name: siRNA-mediated gene silencing by inhibition of translation
namespace: biological_process
def: "An siRNA-mediated post-transcriptional gene silencing pathway that blocks the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically mediate repression of translation if the siRNA perfectly complements elements located in the 3' untranslated region of target mRNAs." [GOC:mah, PMID:18771919]
synonym: "down regulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "down-regulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "downregulation of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "inhibition of translation involved in RNA interference" BROAD [GOC:mah]
synonym: "negative regulation of translation involved in RNA interference" BROAD []
synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah]
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0140766 ! siRNA-mediated post-transcriptional gene silencing
AmiGO
<GOterm>GO:0070549</GOterm>
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